Phytochemical Screening and Metallic Ion Content and Its Impact on the Antipsoriasis Activity of Aqueous Leaf Extracts of Calendula officinalis and Phlebodium decumanum in an Animal Experiment Model
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2019, Vol 16, Issue 3
Abstract
Objectives: The aim of this study was to evaluate the influence of metal ions present in soil as well as in leaf samples of Calendula officinalis and Phlebodium decumanum for the treatment of psoriasis. Materials and Methods: To meet the objective, soil and leaf samples were estimated for metal ions by atomic absorption spectrophotometer to determine the influence in antipsoriatic activity. Thereafter imiquimod-induced dermatitis lesions were created in grouped mice. Two plant extracts (aqueous) separately as well as in combinations and standard Retino-A (0.05%) were used. Psoriasis severity index (PSI) was evaluated according to the phenotypic (redness, erythema, and scales) and histological features (epidermal thickness). Further content of phytochemicals in terms of extract was correlated with the effect of psoriasis activity. Results: We observed redness, erythema, and scales and the histological features and found a progressive reduction (P<0.05) in the severity of psoriatic lesions (redness, erythema, and scales) from days 7 to 21 and decreased epidermal thickness in animals treated with combined extracts at a dose of 200 mg/kg b.w. Furthermore, plant samples procured from the Nandi Hills, Bangalore, showed better uptake of metals with respect to Fe (2.05 mg/kg), Cu (0.78 mg/kg), and Zn (1.12 mg/kg), which showed a positive impact on procurement of maximum amount of extracts that further correlated with the activity, indicating a significant reduction in psoriatic lesions. Conclusion: The results revealed that the significant dose-dependent antipsoriasis activity of combined aqueous extracts of C. officinalis and P. decumanum as well as metal ions had an impact on the procurement of extracts and said activity.
Authors and Affiliations
Kuntal DAS, Someswar DEB, Tejaswini KARANTH
Keywords
Related Articles
- EP ID EP604404
- DOI 10.4274/tjps.galenos.2018.44265
- Views 150
- Downloads 0
Quantitative Structure–Activity Relationship Analysis of Selective Rho Kinase Inhibitors as Neuro-regenerator Agents
Objectives: To understand the role of Rho (serine/threonine) kinases in the treatment of neurological segments, attempts have been made to find potent inhibitors of Rho enzyme by a 2D quantitative structure–activity rela...
Erratum
.
A Comparative Study on the in vitro Antioxidant and Antimicrobial Potentials of Three Endemic Ononis L. Species from Turkey
Objectives: In this study, the antioxidant capacity, antimicrobial activity and phenolic contents of aerial parts and roots extracts of three endemic Ononis L. (Leguminosae) species (O. sessilifolia Bornm., O. basiadnata...
Optimization of Immobilized Aldose Reductase Isolated from Bovine Liver
Objectives: Isolation of enzymes and experiments on them require great effort and cost and are time-consuming. Therefore, it is important to extend the usability of the enzymes by immobilizing them. In this study our pur...
Cytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Lines
Objectives: In recent years, the use of plants for the prevention and treatment of cancer is gaining more attention due to their diverse range of phytochemical constituents and fewer adverse effects. In this study, four...