PHYTOCHEMISTRY AND BIOINFORMATICS APPROACH FOR THE EVALUATION OF MEDICINAL PROPERTIES OF THE HERB, EXACUM BICOLOR ROXB.
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 8
Abstract
Exacum bicolor Roxb. (Gentianaceae) is a phytochemically unexplored traditional medicinal herb, generally distributed in the grasslands of northern Kerala during July-October. The present study through GC-MS analysis revealed the presence of six phytochemical compounds of medicinal importance (two compounds of polyphenolic group viz. 7'-Chloro-3'-(2, 4 dichlorophenyl)-3',4'-dihydrospiro(1, 3- dioxolane- and a’-D- Galactopyranoside, methyl 2,6- bis-0-(trimethylsilyl ) -, cyclic butylboronate, two compounds of alkaloid group viz. 1, 16- Cyclocorynan-16-carboxylic acid, 17-( acetyloxy)-19,20-didehydro-10-methoxy-, methyl ester,(16.xi., 19E)- and 4 – ( 4 – Chlorophenyl)- 5 – morpholin - 4 - yl- thiophen -2- carboxylic acid, ethyl ester, one compound of glycoside group, a’-D- Galactopyranoside, methyl 2,3- bis-0-(trimethylsilyl ) -, cyclic phenylboronate and one compound of steroid group, 9,19 – Cycloergostan – 3 – ol – 7 – one , 4 , 14 – dimethyl –) in addition to number of other compounds. In bioinformatics approach, by using the software, Prediction Activity Spectra for Substances (PASS), molecular formula, pharmacological effects and drug likeness were determined for all the six compounds scientifically which confirm the traditional usage of Exacum bicolor.
Authors and Affiliations
Jeeshna M. V. , S. Paulsamy
Keywords
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