PHYTOESTROGENS IN CANCERS AND SOME OTHER DISORDERS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
Phytoestrogens are natural plant compounds which have a similarity to human estrogens. They hold great potential for health benefits. Recent epidemiological studies have suggested that typical Asian diets, which have always been much higher in these substances than Western diets, appear to be associated with a significantly lower risk of breast, prostate and colon cancer as well as a reduced incidence of heart disease and osteoporosis. The benefits of phytoestrogens to good health and against several disorders are mainly due to the effects they have on the body’s hormonal balance, acting as both agonists and antagonists. Phytoestrogens are thought to act as estrogen agonists by occupying estrogen receptor sites when natural estrogens are unavailable. Phytoestrogens are also thought to act as estrogen antagonists by occupying estrogen receptor sites ahead of the body’s natural estrogens and equally importantly ahead of synthetic estrogens and also environmental estrogens derived from chemical products, otherwise known as bad estrogens or xenoestrogens. The biologically useful forms of phytoestrogens, the metabolites, are dependent for their existence upon a digestive system in good order and complete with adequate microflora capable of converting the basic plant compounds (phytochemicals) into active forms.
Authors and Affiliations
Govind Pandey , Madhuri S.
Keywords
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