PHYTOPHENOLICS COMPOSITION, HYPOLIPIDEMIC, HYPOGLYCEMIC AND ANTIOXIDATIVE EFFECTS OF THE LEAVES OF FORTUNELLA JAPONICA (THUNB.) SWINGLE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 12
Abstract
Objective: Fortunella japonica (Thunb.) Swingle is an evergreen shrub, its whole fruit, including the peel, is eaten. There have been few detailed phytophenolics composition reports on this genus and the hypoglycemic and hypolipidemic effects of the plant were not evaluated. Methods: Structures of the isolated compounds were elucidated by spectral analysis. Serum glucose level, activities of liver enzymes, total protein content, serum lipid profiles, antioxidant parameters and some glycolytic and gluconeogenic enzymes in streptozotocin (STZ)-induced diabetic rats were determined. The evaluation also carried out through determination of liver disorder biomarkers and histopathological examination of liver, kidney and pancreas. Results: Six phytophenolics were isolated, for the first time from the genus Fortunella as well as a sterol compound. Treatment with the ethanolic extract of F. japonica leaves effectively meliorated antioxidant markers and glycolytic enzymes. The histopathological analyzes also confirmed the experimental findings.Conclusion: The results show that the ethanolic extract has hypoglycemic, hypotriglyceridemic and antioxidant effects in STZ-induced diabetic rats, suggesting that this extract supplementation can be useful in preventing diabetic complications associated with hyperlipidemia and oxidative stress.Â
Authors and Affiliations
Nagat S. Abu-gabal, Howaida I. Abd-alla, Naima Z. Mohamed, Hanan F. Aly, Nagwa M. M. Shalaby
Keywords
Related Articles
- EP ID EP578032
- DOI -
- Views 55
- Downloads 0
EVALUATION OF ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF FENUGREEK (TRIGONELLA FOENUM-GRAECUM) EXTRACTS
Objective: The present investigation was performed to evaluate the antimicrobial potential of Trigonella foenum-graecum leaves extracts and to elucidate the presence of phytochemicals responsible for its biological activ...
A CASE REPORT ON TAKAYASU’S ARTERITIS
Takayasu’s arteritis (TA) is a rare large-vessel vasculitis that affects large arteries, mainly the aorta and its branches. It is also called a pulseless disease because of diminished or absent pulses in the upper extr...
SERUM LIPID LEVELS IN PERIODONTITIS PATIENTS: A CASE-CONTROL STUDY
Objective: We aimed to evaluate serum lipid levels in periodontitis patients and compared with healthy subjects.Methods: A case-control study was conducted among 30 participants in the age group of 35-60 y, including 15...
FREE RADICAL LOAD IN LYMPHOID ORGANS (SPLEEN AND THYMUS) OF INDIAN GOAT CAPRA HIRCUS: ROLE OF SEX, SEASON AND MELATONIN
Objective: Lymphoid organs (i.e. spleen and thymus) are important due to functional dynamicity. As a result, the generated free radicals may limit their function. Thus, present study was aimed to note seasonal and sex de...
EVALUATION OF IMMUNOMODULATORY ACTIVITY OF EXTRACT FROM RIND OF NEPHELIUM LAPPACEUM FRUIT
Objective: Nephelium lappaceum Linn (Sapindaceae), also known as Rambutan is a tropical fruit native to Malaysia. The rind of Rambutan, which is normally discarded, has been used in the present research work to explore t...