pKa Determination of Pharmaceutical Active Agents: The Analytical Method of Choice
Journal Title: Medicinal & Analytical Chemistry International Journal - Year 2018, Vol 2, Issue 4
Abstract
The acid-base dissociation constant (pKa) of a drug is a major physicochemical parameter that influences biopharmaceutical characteristics of drugs and other chemical substances [1]. The pKa distributions of drugs are influenced by two main factors namely; (i) the nature and frequency of occurrence of the functional groups commonly seen in drug molecules and the typical range of pKa values involved, (ii).the biological targets the drug molecules are designed to interact.
Authors and Affiliations
Mbah CJ
Keywords
Related Articles
- EP ID EP547487
- DOI -
- Views 73
- Downloads 0
Pharmaceutical Industry and the Role of an Analyst
Analytical chemistry prospers because it is continuously evolving and hence changing. The users of analytical instruments increasingly are exploiting their inventiveness as chemical measures to learn, to measure and inve...
Men's Condomination from Incontinence
The construction of the male condom is proposed, which excludes mechanical damages of the penis from contact with its walls. To do this, the condom has a spherical extension without a joint, and the fastening is carried...
Angelic Acid, Diabolic Acids, Draculin and Miraculin Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment Under Synchrotron and Synchrocyclotron Radiations
In the current editorial, we study Angelic Acid, Diabolic Acids, Draculin and Miraculin Nano molecules incorporation into the Nano Polymeric Matrix (NPM) by immersion of the Nano Polymeric Modified Electrode (NPME) as mo...
Phytochemical Evaluation and Antioxidant Properties of Three Medicinal Plants Extracts
Objective: Medicinal plant over the years has been used to treat many diseases such as Diabetic, cancer, tumour, ulcers and bacterial. This study aimed at conducting the phytochemical analysis and in vitro antioxidant ac...
Energy Deposition by High Energy Particle Beam Radiation
The mean excitation energies of some atoms and some ions are discussed. In any series, the largest changes in mean excitation energy for single electron occupation number changes occur when the change involves different...