Plasma Cell Disorders
Journal Title: Chettinad Health City Medical Journal - Year 2017, Vol 6, Issue 2
Abstract
Plasma cell disorders are monoclonal neoplasm due to underlyng clonal plasma cell or B cell. This is a group of disorders that comprise of multiple myeloma, Waldenstrom’s macroglobulinemia, amyloidosis and heavy chain disease together called monoclonal gammapathy. Immunoglobulins or its fragments secreted by these neoplastic plasma cells cause clinical manifestations. Protein electrophoresis identifies the presence of these monoclonal proteins whereas immunofixation identifies the fragments like heavy or light chain and clonality, flow cytometry identifies the cell type. Treatment modalities with drugs and stem cells are focused to prolong survival by reducing tumour load and its effects.
Authors and Affiliations
Lanord Jawahar, Ananthkumar PK, Anitha A
Keywords
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