Biomarkers of Acute Kidney Injury
Journal Title: Chettinad Health City Medical Journal - Year 2018, Vol 7, Issue 2
Abstract
Acute kidney injury(AKI) is triggered by number of factors like ischaemia, nephrotoxins etc and is associated with increased morbidity and mortality. AKI diagnosis is usually based on the rise in serum creatinine or reduction in urine output. Though creatinine is used as an indicator of kidney function ,it is a suboptimal marker of injury as it rises only after around 50% of function loss. The delay in diagnosis of kidney injury prevent timely management decisions raising the demand for sensitive, specific and reliable biomarkers that can stratify correctly the extend of renal damage. A number of novel biomarkers are currently available to represent kidney injury and kidney function. Here we make an effort to present the main features of emerging biomarkers. An analytical approach attempted to know whether the new biomarkers diagnose acute kidney injury earlier than traditional tests, whether they can identify patients who need renal replacement therapy, does it improve patient outcome and when it should be measured.
Authors and Affiliations
Ananthakumar PK, Sabarathnavel R, Srinivasan TV
Keywords
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