An Overview of Common Symptoms and their Management in Chronic Kidney Disease
Journal Title: Chettinad Health City Medical Journal - Year 2018, Vol 7, Issue 2
Abstract
CKD is a global health issue associated with increased financial burden and affects the quality of life to a vast extent. The symptoms confronted by patients in various stages of chronic kidney disease are very debilitating. The most common symptoms of CKD are itching, sleep disturbance, anorexia, fatigue, muscle wasting, nausea, vomiting, chronic pain, shortness of breath, bleeding and sexual dysfunction. Most of the symptoms are due to increased proinflammatory mediators like IL-6 and TNF α. Recent research studies have discovered new biochemical substances like orexin, ghrelin, melatonin and adiponectin as mediators of some of the symptoms like fatigue and muscle wasting. This review focuses on the possible pathophysiological mechanisms and management of the above mentioned symptoms.
Authors and Affiliations
Vinu B, Durga K, Balaji R
Keywords
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