Plasma Factor VII and Histidine-Rich Glycoprotein as A Potential Markers in Pre Eclampsia
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 5
Abstract
<strong>Background: </strong>Preeclampsia (PE) is a complex and serious multi-system disorder of pregnancy with a worldwide incidence of 5-7% and contributes significantly to maternal and perinatal morbidity and mortality. Normal pregnancy is associated with a local hypercoagulable state that becomes more profound in PE. Histidine-rich glycoprotein (HRG) is a protein interacting with angiogenesis, coagulation, and inflammatory responses, processes known to be altered in preeclamptic pregnancies. <strong>Aim of the work: </strong>Is to analyze changes in the circulating levels of plasma factor VII (Plasma F VII) and HRG in women developing PE and to evaluate them as markers for early diagnosis of PE. <strong>Subjects and Methods: </strong>This study was carried out on 80 pregnant women after 20 weeks of gestation. The subjects were divided into: Group I (G1): 40 cases with preeclampsia; Group II (G2): 40 normal pregnant women who were matched for age and gestational period. Plasma FVII and HRG were measured by ELISA <strong>Results: </strong>Plasma FVII levels were significantly higher in G1 (206.22 ± 46.25 ng/ml) as compared to G2 (97.46 ± 21.95 ng/ml) (p<0.001). Significant positive correlation of plasma FVII with fibrinogen and significant negative correlation with platelet count and HRG were detected. At cut off 125.75 ng/ml plasma FVII levels shows high sensitivity and specificity (95%). HRG levels were significantly lower in G1 (37.1 ± 7.52 pg/ml) as compared with G2 (79.87±24.15 pg/ml) (p<0.001). HRG shows significant positive correlation with platelet count and significant negative correlation with each of fibrinogen and plasma FVII. At cut off 46.45 pg/ml. HRG shows high sensitivity (92.5%) and specificity (87.5%). <strong>Conclusion: </strong>Plasma FVII and HRG can be used as early marker for detection of PE.
Authors and Affiliations
Eman Helal
Keywords
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- EP ID EP584176
- DOI 10.12816/ejhm.2018.9539
- Views 122
- Downloads 0
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