Plasma Homocysteine, Methyl-Malonic Acid, Vitamin B12 and Folate Levels in Adult Nigerian Sickle Cell Anaemia Patients
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 6
Abstract
Aims: To compare the mean levels of plasma total Homocysteine (tHct), Methylmalonic acid (MMA), vitamin B12, folate and haematological parameters(PCV, WBC, Platelet counts, MCV, MCH, MCHC) among adult SCA patients in steady state (SS), SCA in (VOC) and age and sex matched controls in order to determine significant differences. Study Design: Case-control study. Place and Duration of Study: Department of Haematology and Department of Chemical Pathology, University College Hospital, Ibadan, Nigeria between March 2012 and July 2012. Methodology: We included 60 SCA patients (30 in VOC, 30 in Steady State; and 30 age and sex matched controls. Plasma tHct, MMA, folate and vitamin B12 were assessed using HPLC and haematological parameters were determined using haematological autoanalyzer (Syxmex Kx21). Results: The mean plasma tHct, MMA, vitamin B12 of SCA patients (VOC and SS) were significantly lower (p=0.000) compared to control population but the mean folate levels were comparable (p=0.085). The SCA (in VOC) had significantly lower (p=0.000) MMA and folate levels compared to SS group but the SS group had significantly lower (p=0.001) tHct level compared to VOC group. While the PCV, Hgb, MCV, and MCH were significantly lower; the WBC, platelet count and the MCH were significantly elevated in SCA patients compared to controls. Conclusion: A larger, better controlled, multicenter study is required to confirm lower tHct and MMA found in SCA groups compared to control group and higher tHct in SCA (VOC) but higher MMA level in SCA (SS) when VOC and SS groups were compared. The haematological parameters in SCA groups were not in keeping with macrocytic anaemia but were indicative of chronic haemolytic and inflammatory process.
Authors and Affiliations
J. A. Olaniyi, K. S. AKinlade, A. D. Atere, O. G. Arinola
Keywords
Related Articles
- EP ID EP348591
- DOI 10.9734/BJMMR/2014/3989
- Views 57
- Downloads 0
Lung Function in Sudanese Children and Adolescents with Type 1 Diabetes Mellitus
Background: Diabetes Mellitus Type 1 (DMT1) is a chronic, debilitating and multifactor disease that is emerging as an important health problem in Sudan. The aim of this study was to investigate the lung functions in Suda...
A Rare Case Report of Parotid Cavernous Hemangioma in an Adult
Hemangioma is a common soft tissue lesion in oral and maxillofacial region. However, hemangioma in the parotid gland is a rare presentation in adult population with only few reports of cavernous hemangioma within the par...
Correlation of Multidrug Resistance and Plasmid Profile in Extended Spectrum Beta Lactamase Producing Escherichia coli Isolated from Patients Suspected of Urinary Tract Infection
Aims: To determine the prevalence of extended spectrum beta lactamase producing Escherichia coli (ESBL E. coli) strains among the total isolates and study the association between the antibiotic resistance and plasmid pro...
Applications of Low Energy Megavoltage X-ray Beams in Cancer Radiotherapy
A review on the applications of low energy megavoltage (MV) X-ray beams (1-4 MV) in cancer radiotherapy is presented. Firstly, the physical characteristics of low energy megavoltage X-ray beams are reviewed in terms of p...
Clinical Strategies for Managing Dental Caries in Egypt: Opinions of General Practitioner Dentists
Background: To assess the approach of GPDs in Upper Egypt regarding preventive and restorative treatments for various stages of carious lesion development. Methods: A 42-item questionnaire was constructed for obtaining t...