Plasma N-terminal Pro Brain Natriuretic Peptide as a Prognostic Biomarker in Children with Pulmonary Hypertension
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 23, Issue 6
Abstract
Aim: To evaluate plasma level of N-terminal pro brain natriuretic peptide (NT pro-BNP) as a prognostic biomarker in children with pulmonary hypertension (PH) due to congenital heart disease (CHD). Study Design: Prospective case controlled study. Place and Duration of the Study: Pediatric cardiology department, Tanta University hospital, Egypt during the period from February 2016 to February 2017. Methodology: Thirty children with PH due to CHD were enrolled as patients group. Thirty healthy children of matched age and sex were taken as control group. All children were evaluated by echocardiography and plasma level of NT pro-BNP at admission. We followed up patients for 6 months after discharge for adverse effects, mortality or readmission. Results: Plasma level of NT pro-BNP was significantly elevated in patient group than control group (P=0.001). Both systolic and diastolic functions of left ventricle and right ventricle were impaired in patient group compared to control group. Moreover, both left ventricular and right ventricular dimensions were increased in patient group than control group. Plasma NT pro-BNP was significantly elevated in patient with unfavorable prognosis compared to patients with favorable prognosis (P<0.001). Plasma NT pro-BNP level was positively correlated with heart rate, estimated systolic pulmonary artery pressure and left ventricular end systolic dimension. While, it was significantly inversely correlated with left ventricular fraction shortening, left ventricular E’/A’ ratio, right ventricular outlet fraction shortening and right ventricular E’/A’ ratio. Receiving operating characteristics curve showed that sensitivity of NT pro BNP as a prognostic biomarker in PH patients was 100% and specificity was 92% at cutoff value of more than 103 pg/ml. Conclusion: NT pro-BNP may serve as a reliable biomarker for predicting adverse outcome in children with PH due to CHD.
Authors and Affiliations
Fatma Abd-Rabo, Doaa El-Amrousy, Hesham El-Serogy, Amr Zoair
Keywords
Related Articles
- EP ID EP312442
- DOI 10.9734/JAMMR/2017/35937
- Views 72
- Downloads 0
Possible Benefits of the Whole Body Vibration in the Treatment of Complications in Stroke Patients
Aims: A stroke is a neurological disorder and muscle weakness is the most prominent impairment. Whole-body vibration (WBV) is a possible modality of exercise that is useful for improving physical capacity, bone mass, bal...
Increasing Number of Comorbidities is Related to Delay to Surgical Management of a Perforated Peptic Ulcer in Patients who Died
Introduction: The incidence of peptic ulcer disease has declined since the introduction of medical therapy, but the rate of perforated peptic ulcer and associated mortality has remained relatively constant. Delay to defi...
Complex Changes in Blood Biochemistry Revealed by a Composite Score Derived from Principal Component Analysis: Effects of Age, Patient Acuity, End of Life, Day-of Week, and Potential Insights into the Issues Surrounding the ‘Weekend’ Effect in Hospital Mortality
Aims: To determine if a score (PCA score derived from Principal Component Analysis), a validated score of frailty and mortality, based on 12 blood biochemistry parameters can shed light on the issue of patient acuity, en...
Applications of Low Energy Megavoltage X-ray Beams in Cancer Radiotherapy
A review on the applications of low energy megavoltage (MV) X-ray beams (1-4 MV) in cancer radiotherapy is presented. Firstly, the physical characteristics of low energy megavoltage X-ray beams are reviewed in terms of p...
“Toxic Butts”: Key Performance Indicators from a California Statewide Social Media Campaign for Tobacco Control
Background: The “Toxic Butts” campaign was funded by the California Tobacco Control Program as part of a tobacco product waste toolkit. The campaign was to function as a case study, helping to establish best practices fo...