The Intricate Relationship between Insulin Resistance and Adipokines in Non-obese Patients with Polycystic Ovarian Syndrome
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 18, Issue 5
Abstract
Background: Dyslipidemia and metabolic complications related to Insulin resistance are closely linked to patients suffering from polycystic ovarian syndrome (PCOS). Aims: To find out the changes in serum testosterone, leptin and adiponectin levels and explore their relative importance in alterations of insulin resistance (IR) in non obese PCOS patients. Study Design: Hospital based, case control, non interventional study. Both cases and control subjects were selected following the method of convenience according to prefixed inclusion and exclusion criteria. Methodology: In 33 non obese PCOS patients and 35 controls Leptin, insulin, testosterone, leutinizing hormone (LH), follicular stimulating hormone (FSH) and adiponectin were measured by enzyme linked immunoassay (ELISA). Fasting plasma glucose (FPG) was measured by spectrophotometric method. Insulin resistance (IR) was calculated through homeostatic model for assessment of insulin resistance (HOMA-IR) technique. Waist hip ratio (WHR) and body mass index (BMI) were calculated as anthropometric parameters to assess distribution of body fat. Results: Mean +/- Standard error of mean values for the HOMA-IR (1.98 +/- 0.19 vs 1.04 +/ - 0.04), FBG (4.98 +/- 0.27 vs 4.52 +/- 0.07) serum leptin (12.55 +/- 1.00 vs 8.23 +/- 1.03), serum testosterone (1.19 +/- 0.07 vs 0.41 +/- 0.04), serum LH (30.74 +/- 1.73 vs 5.69 +/- 0.44), serum FSH (10.93 +/- 0.38 vs 6.29 +/- 0.46) and WHR (0.82 +/- 0.01 vs 0.74 +/- 0.01) were significantly elevated in the PCOS patients compared to the control group. On the other hand, serum adiponectin was significantly decreased in PCOS group (11.41 +/- 1.21 vs 23.55 +/- 2.94) while BMI showed no significant difference. Although, individual bivariate correlation analysis suggested IR to be significantly associated with serum leptin, adiponectin, testosterone and WHR, but multivariate linear regression analysis revealed significant predictive values for serum leptin (β = .467,), adiponectin (β = -.324,) and testosterone (β = .266,) only on the HOMA-IR. Conclusion: Increased androgen and leptin along with decreased adiponectin levels have crucial determining effects on increased IR that might play a major role in mediating the pathogenesis and metabolic abnormalities in non obese PCOS.
Authors and Affiliations
Suparna Roy, Anindya Dasgupta, Rituparna Maji, Nibedita Chattopadhyay, Arati Biswas
Keywords
Related Articles
- EP ID EP341044
- DOI 10.9734/BJMMR/2016/29265
- Views 75
- Downloads 0
Non-Helicobacter pylori, Non-NSAID Peptic Ulcer Disease: An Important Consideration in the Evaluation of Patients with Gastric or
Peptic ulcers are common although the pattern of aetiology is changing. The traditionally most frequent causes of Helicobacter pylori infection and non-steroidal anti-inflammatory toxicity are likely to assume less relat...
Important Signs in Musculoskeletal MRI
The purpose of this article is to review the common MRI signs of musculoskeletal pathology. In this article, 15 classic MRI signs used in musculoskeletal radiology are presented and described. These signs include the ant...
Orthodontic Treatment Combination with Auto Transplantation for the Management of Impacted Maxillary Left Lateral Incisor and Canine: An Interdisciplinary Approach
Aims: For the orthodontic treatment of the complex cases, the interdisciplinary team work is of utmost importance, which leads to the predictable outcome with excellent treatment. The prime aim of this rare case report i...
Association between XRCC3 Thr241Met Polymorphism and the Risk of Cancer in Northern Brazil
Aims: Cancer is a genetic disease characterized by an unbalance between cell growth and regulatory factors. The gene XRCC3 encodes a protein that contributes to the integrity of the genome and XRCC3 Thr241Met variants ha...
The Impact of Body Mass Index on the Surgical Outcomes in Open Rectal Cancer Surgery
Technical difficulties which affect the outcomes of abdominal operations are common in obese patients, especially in rectal and gastric cancer cases. In several studies, it has been shown that increased body mass index (...