Plasma vitamin D levels in obese children: relationship with selected anthropometric and metabolic parameters
Journal Title: Postępy Nauk Medycznych - Year 2014, Vol 27, Issue 10
Abstract
Introduction. The prevalence of overweight and obesity is increasing worldwide, particularly among children and adolescents. Investigations report a correlation between serum 25(OH)D level and body mass. Plasma 25(OH)D concentration is lower in obese children than normal-weight children. Recent studies suggest that vitamin D deficiency is associated with higher risk of: impaired glucose tolerance, diabetes mellitus, dyslipidemia, metabolic syndrome, cardiovascular disease and hypertension.Aim. The aim of the study was to investigate the correlation between serum 25(OH)D level in obese children and their anthropometric and metabolic parameters.Material and methods. A retrospective analysis of obese patients diagnosed at the Department of Pediatrics and Endocrinology of the Medical University of Warsaw was performed. The study included a total number of 65 obese patients, aged 5-18 and involved the analysis of selected biochemical parameters such as Oral Glucose Tolerance Test (OGTT), fasting blood glucose, insulin, total cholesterol, HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglyceride (TG), 25(OH)D. Atherogenic index of plasma (AIP) and HOMA-IR index were calculated and a anthropometric measurements were taken.Results. Sixty five patients (33 female and 32 male) aged 12.9 ± 2.96 were included in the analysis. In 51 (78.5%) of them serum 25(OH)D level was < 20 ng/ml, BMI = 30.89 ± 5.28, SDS BMI = 4.26 ± 1.91. In 14 children (21.5%) serum 25(OH)D level was > 20 ng/ml, BMI = 27.87 ± 4.20, SDS BMI = 3.04 ± 1.44. The relationship of serum 25(OH)D level to biochemical and anthropometric parameters were as follows: 25(OH)D levels were negatively correlated with SDS BMI, HOMA-IR and fasting insulin level.Conclusions. For obese children we observe a negative correlation between BMI, HOMA-IR, fasting blood insulin and 25(OH)D serum concentrations.
Authors and Affiliations
Maria Krajewska, Anna Kucharska, Beata Pyrżak
Keywords
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