Point Prevalence Survey on Antibiotic Use and Class-1 Integron Associated Antibiotic Resistance In No (1) DSGH, Yangon
Journal Title: International Journal of Multidisciplinary Research and Analysis - Year 2023, Vol 6, Issue 04
Abstract
Antimicrobial resistance is becoming a global health emergency. Likewise, multidrug resistance of gram-negative bacteria also has a high impact on public health. This cross-sectional study aimed to study antibiotic prescription patterns and class-1 integron-associated antibiotic resistance among gram-negative bacteria in No (1) Defence Services General Hospital, Yangon. The research was conducted by modifying the WHO PPS methodology. All eligible patients who were prescribed antibiotics on the day of the survey were investigated. Among the participants whose culture samples were sent to the laboratory, gram-negative bacterial culture samples undergone the class 1 integron test. There were 441 patients from 12 eligible wards with a total of 781 prescriptions in the study in January and July of 2020. The leading indication was surgical prophylaxis 257 (32.91%). Cephalosporins and Penicillins were mostly prescribed antibiotic classes. Among bacterial culture, (52.31%) were multidrug- resistant, and (47.69%) were gram-negative. Class 1 integron positivity and rate of multidrug resistance among GNB were (54.84%) and (90.32%). Class 1 integron positivity among multidrug resistance was (60.71%). There was no statistically significant association between class 1 integron and multidrug resistance in this study. Three and more antibiotic prescriptions, surgical prophylaxis, and old age group were positively associated with multi-drug resistance with (AOR=8.9, 95% CI; 2.3-34.2), (AOR=21.1, 95% CI; 2.1-210.0), and (AOR=4.6, 95%CI; 1.2-17.2) respectively. Antibiotic policy and standard treatment guidelines for the tertiary military hospital should be developed while surveillance of antibiotic resistance must be performed simultaneously.
Authors and Affiliations
Aung Ba Tun, Kyaw Khine Win, Tun Tun Win, Kyaw Wunna, Khine Khine Su, Kyaw Myo Tun
Keywords
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- EP ID EP714901
- DOI 10.47191/ijmra/v6-i4-22
- Views 60
- Downloads 0
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