POLYMER CROSS LINKED SILK PROTEIN AS A PHARMACEUTICAL EXCIPIENT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 1
Abstract
Silk proteins are natural proteins in silk cocoons. Silk cocoons contain 25% - 30% of sericin, remaining is constituted by fibroin. The present study aims to extract the sericin and cross link it with suitable polymers. And study the influence of cross linked sericin on tablet properties. Sericin was extracted and was cross linked with Gelatin, Gurgum, PVP, Acrylamide. Cross linked sericin was evaluated for binding property of tablets. It was found that sericin loses its binding efficiency by cross linking it with selected polymer. Presence of cross linked sericin in tablet formulation did not influence the dissolution of either the water soluble drug (propranolol HCl) or water insoluble drug (indomethacin). However sericin cross linked with acrylamide retarded drug release. It may be due to formation of Inter Penetrating Polymer Network (IPN). Cross linked sericin could not satisfy the requirements of pharmaceutical excipient for oral solid dosages form. Cross linked sericin with acrylamide exhibited swelling property can further explored for topical controlled release.
Authors and Affiliations
Gouri Shankar , Parthasarathi Kulkarni , Ajay Kulkarni , Mudit Dixit
Keywords
Related Articles
- EP ID EP124716
- DOI -
- Views 87
- Downloads 0
FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF FAMOTIDINE USING NATURAL POLYMERS
In the present investigation effervescent floating matrix tablets of famotidine are formulated to achieve gastric retention for a period of 8 to 10 hrs. Famotidine is H2 receptor antagonist widely prescribed in gastric u...
CHEMICAL COMPOSITION AND ANTIOXIDANT ACTIVITY OF ESSENTIAL OIL FROM CURCUMA AMADA ROXB.
This study was designed to examine the chemical composition and in vitro antioxidant activity of essential oil of Curcuma amada Roxb. The GC- MS analysis of the oil resulted in the identification of 12 compounds. β-myrce...
PRELIMINARY PHYTOCHEMICAL ANALYSIS AND ACUTE ORAL TOXICITY STUDY OF MUCUNA PRURIENS LINN. IN ALBINO MICE
Mucuna Pruriens Linn. is an annual, climbing shrub which has an important place among aphrodisiac herbs in India since the ancient times. The plant has been using traditionally for many medicinal purposes such as Inferti...
SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF AMBROXOL HYDROCHLORIDE, LEVOCETIRIZINE DIHYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE IN TABLET DOSAGE FORM
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of ambroxol hydrochloride, levocetirizine dihydrochloride and pheny...
EVALUATION OF ANTIMICROBIAL ACTIVITY OF THE FRUITS OF CUCUMIS TRIGONUS ROXB.
The antibacterial and antifungal activities of the successive extracts (petroleum ether (40-60ºC), benzene, chloroform, ethanol and water) of the fruit of Cucumis trigonus Roxb. (Fam. Cucurbitaceae) have been carried out...