Polymorphism A/C in exon 7 of the bovine estrogen receptor α (ERα) gene and its association with functional and milk production traits in Red-and-White cattle
Journal Title: Animal Science Papers and Reports - Year 2011, Vol 29, Issue 4
Abstract
Due to the functions that estrogens play in the regulation of reproduction, development of mammary gland, growth and differentiation of cells, estrogen receptors and their genes are considered candidates for molecular markers of production and functional traits in farm animals. In this study, using the SSCP and DNA sequencing, we found a novel single nucleotide polymorphism (SNP) in the coding region of the estrogen receptor α (ERα) gene – the A/C transversion at position 323,396 (relative to the start of transcription site), in exon 7, that could be also detected with RFLP-CfrI. This mutation causes the amino acid replacement – Asparatic acid/Alanine in the ligand-binding domain (LBD) of the receptor. The ERα A/C (RFLP-CfrI) genotypes were estimated in a cohort of 489 cattle of different breeds, including 355 Red-and-White cows. Association was studied between ERα genotype and dairy production traits (milk yield and composition) and functional traits (reproduction, length of productive life). The results showed that ERα A/C genotype affected significantly only a few traits of interest: protein and fat content in milk, sex of calves born. No associations were detected between ERα genotype and milk yield and reproduction traits of Red-and-White cows.
Authors and Affiliations
Tomasz Szreder, Jolanta Oprządek, Beata Żelazowska, Edward Dymnicki, Lech Zwierzchowski
Keywords
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