Polymorphism rs3087243 is associated with the occurrence of ankylosing spondylitis in the West Algerian population
Journal Title: UNKNOWN - Year 2017, Vol 1, Issue 2
Abstract
Background: Numerous studies have shown that polymorphism rs231775 of the CTLA4 gene is strongly implicated in the development of ankylosing spondylitis (AS). Other polymorphisms of this gene are candidates that may have an additional effect in susceptibility to AS. For the first time, we searched for the association of rs3087243 polymorphism located in the 3'UTR region of the CTLA4 gene with the development of SA in the Algerian population. Methods: The study involved 200 subjects (80 AS patients recruited at the rheumatology service and 120 healthy individuals unrelated). Genotyping was performed by real-time PCR (Taqman®). Analysis of the results was carried out by IBM.SPSS.Statictis® software. Results: The distribution of allele frequencies showed a significant association between the GG genotype of the polymorphism rs3087243 and AS risk (OR= 1.77 [0.98-3.21], p=0.004). Conclusion: Our data would suggest that the 3'UTR region of the CTLA4 gene could have an impact on the development of SA in the West Algerian population. These results need to be confirmed on a larger sample.
Authors and Affiliations
Chahinez Amira DAHMANI, Elisabeth PETIT-TEIXEIRA, Abdallah BOUDJEMA
Keywords
Related Articles
- EP ID EP261226
- DOI 10.26415/2572-004X-vol1iss2p29-30
- Views 45
- Downloads 0
Contextual hybrid-based recommendation of Pubmed articles
Background: The amount of information in the medical field has been growing day by day. Also new medical articles about the preoccupied disease are published each day and the updated information is very required by physi...
Bioactive molecule of essential oil of Cuperssus sempervirence Mill – in vitro other treatment against microbial pathogenesis
Background: Each year, many million people attract infections caused by bacteria, fungi, virus,and parasite, infectious diseases reached at high rate, and the problem of emerging and reemerginginfections becomes a seriou...
Detection of muscle fatigue, from statistical methods to software applications
Background: Muscle fatigue has become increasingly present in our daily lives. This is related to lifestyle difficulties. Several methods were proposed in order to detect the muscle fatigue. This report proposes a short...
Toxicological risks of water and human health, contribution to the biological treatments in the dam of Ain Zada
Background: Freshwater fish play a role in detoxification of certain germs and pathogens of bacteria. Variation of the content of pathogenic bacteria are, mainly, total coliform, fecal coliform, and fecal streptococci in...
An Efficient Algorithm for Multimodal Medical Image Fusion based on Feature Selection and PCA Using DTCWT (FSPCA-DTCWT)
Background: During the two past decades, medical image fusion has become an essential part ofmodern medicine due to the availability of numerous imaging modalities (e.g., MRI, CT, SPECT,etc.). This paper presents a new m...