Polynuclear neutrophil variation and oxidative stress in Type 2 Diabetics
Journal Title: The Journal of Medical Research - Year 2018, Vol 4, Issue 1
Abstract
Context: Chronic hyperglycemia and inflammation in type 2 diabetics may be correlated with oxidative stress, which is the basis of micro- and macro-angiopathic complications. The evolution of this inflammation resulted in the accumulation of neutrophils at the inflammatory site, the latter are in the basal state in a state of constant preactivation for the production of O2 0- . Objectives: This study aimed to determine the quantitative and morphological variation of neutrophils; and to identify the level of correlation between neutrophil levels and oxidative stress in type 2 diabetics in Lubumbashi. Material and methods: Spectrophotometric and microscopic methods were used to evaluate glycemia and neutrophils in the samples. Results: The study included 27 confirmed type 2 diabetics, including 52% of women. Their average age was 56.33 ± 11.79 years old. An increase in neutrophil count and a deviation of the Arneth curve were observed in 37.03% and 71.14%, respectively, of diabetic subjects. Conclusion: This study showed an increase in neutrophils in type 2 diabetics. This may be related to an indirect activation of the immune system in these subjects
Authors and Affiliations
Arsène Kabamba Tshikongo, Reagen Kilela Songela, Joelle Kibulu Koke, Sifa Semakuba Mawazo, Zet Lukumwena Kalala, Albert Longanga Otshudi
Keywords
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- EP ID EP521878
- DOI 10.31254/jmr.2018.4105
- Views 113
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