PON1 Inter- individual Enzymatic Activity Variation Among Acutely Intoxicated Agricultural Workers Presented With OPCs Presented To PCC-ASU, Egypt
Journal Title: Annals of Environmental Science and Toxicology - Year 2017, Vol 2, Issue 1
Abstract
Organophosphate compounds result in numerous toxicities because of their widespread usage and easy accessibility especially in the developing world’s agricultural communities. PON1 activity towards OPCs shows inter individual variations. Isoforms of the enzyme differing in their PON1 activity result from amino acid substitutions at positions 192 which is glutamine (Q) to arginine (R) and at 55 which is leucine (L) to methionine (M) thus rendering the identification of individuals’ PON1 all enzymes of value in treatment of patients suffering from OP intoxication The aim of this work is to study the influence of genetic variation of PON1 gene on paraoxonase enzyme activity in cases of acute organ phosphorus compounds poisoning. These compounds exert their toxicity primarily through inhibiting acetyl cholinesterase (AChE) enzyme. This study was carried out at the Poison Control Center (PCC) of Ain Shams University Hospitals, Cairo, Egypt. Paraoxonase enzyme activity: It was determined according to the method of Furlong et al. (1988).
Authors and Affiliations
Abd El AL Amira Haridy, Fawzi Marwa Mohamed, AL-Khafif Mohamed Ahmed, El-Zemaity Mohamed EL-Said
Keywords
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- EP ID EP560454
- DOI 10.17352/pjest.000014
- Views 46
- Downloads 0
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PON1 Inter- individual Enzymatic Activity Variation Among Acutely Intoxicated Agricultural Workers Presented With OPCs Presented To PCC-ASU, Egypt
Organophosphate compounds result in numerous toxicities because of their widespread usage and easy accessibility especially in the developing world’s agricultural communities. PON1 activity towards OPCs shows inter indiv...