Positive Correlation Between Platelet Parameters and Genetic Markers of Thrombophilia Panel in Recurrent Pregnancy Loss
Journal Title: Eurasian Journal of Family Medicine - Year 2018, Vol 7, Issue 1
Abstract
Aim: Recurrent pregnancy loss (RPL) defined as 3 or more miscarriages before 20 weeks of gestation by the World Health Organization, and is a common complication during pregnancy, especially for early gestation and affects about 1–5 % of pregnant. In this study, we analyzed mean platelet volume (MPV), platelet count (PLT) values, Factor II g.20210G>A, Factor V Leiden, MTHFR (C677T, A1298C), PAI-1, β-fibrinogen, Factor XIIIA (V34L) and glycoprotein IIIa (L33P) polymorphisms of patients who have RPL history and searched the relationship between genetic thrombophilia markers and platelet parameters in RPL. Methods: A retrospective, clinical trial was performed by reviewing the recurrent pregnancy loss history of 229 patients, and 200 controls. The results of the genetic thrombophilia panel were used to classify the study and control group into low, intermediate and high risk for thrombophilia groups. Results: Factor II g.20210G>A (p=0.035), Factor V Leiden mutations (p=0.027) and PAI-1 (4G/5G) (p<0.001), β-fibrinogen homozygous polymorphisms (p=0.004) and Factor XIIIA (V34L) homozygous polymorphisms (p=0.001) are significant for recurrent pregnancy loss. According to platelet parameters; additively, there was significant difference between MPV and PLT values of RPL and control group, thrombophilia mutations and polymorphisms also have a significant effect on MPV and PLT values in RPL, according to severity of thrombophilia mutations or polymorphisms (p<0.001). Conclusion: Severities of genetic thrombophilia markers have a significant effect on MPV and PLT values in RPL.
Authors and Affiliations
Haktan Bagis Erdem, Ahmet Cevdet Ceylan, Abdulkadir Kaya, Taha Bahsi, Zeynep Sever Erdem, Ibrahim Sahin, Abdulgani Tatar
Keywords
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- EP ID EP431627
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