Possibilities of the diagnosis and prevention of diabetic nephropathy development in children with type 1 diabetes mellitus
Journal Title: Здоров`я дитини - Year 2019, Vol 14, Issue 5
Abstract
The rapid increase in the prevalence of type 1 mellitus (DM) has made the study of this pathology in children a priority. Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus and is characterized by damage to the kidney vessels, development of glomerulosclerosis and chronic renal failure in the future. The asymptomatic course of the disease in the early stages complicates the diagnostic and prophylactic actions. Microalbuminuria develops 5–7 years after diagnosis of diabetes and is not the main indicator of kidney damage in the early stages of DN. Biomarkers play an important role in early diagnosis, analysis of the progression of the pathological process and adequate treatment. The purpose of the review is to study potential early biomarkers of DN and their structural and functional characteristics. For writing the article, a search was made on the Scopus and Web of Science databases. The review contains information about 13 markers of functional impairment of the glomerular tubular apparatus of the kidney. The consequences of activation of oxidative stress, inflammatory and fibrotic processes at the level of the glomerular and tubular kidney apparatus are presented. A cascade of metabolic disturbances was considered, the trigger factor of which is hyperglycemia. The correlations, the expediency of using markers in patients of different ages and with different durations of type 1 diabetes were revealed. The biomarkers presented are candidates for the panel of diagnostic markers for DN and an addition to the existing standards for diagnosing lesions of the tubulointerstitial apparatus of the kidneys in case of DM. Prevention of diabetic complications remains an urgent task for modern researchers.
Authors and Affiliations
A. M. Loboda, I. O. Shandyba
Keywords
Related Articles
- EP ID EP638305
- DOI 10.22141/2224-0551.14.5.2019.177410
- Views 67
- Downloads 0
Cytomegalovirus Infection in Children: Treatment Approaches in Different Course of Infection
Diseases caused by cytomegalovirus infection largely determine the health status of children that is due to the spread of infection and often due to its severity. The paper presents approaches to rational and effective t...
Immunological Features of Chronic Gastroduodenitis in Children on the Background of Giardiasis
In the article, we have analyzed the immunological features of chronic gastroduodenal pathology in children with concomitant giardiasis. Objective: tо identify specific immunological criteria for chronic gastroduodenal p...
The Effectiveness of Sublingual Allergen-Specific Immunotherapy in Children with Allergic Rhinitis
The article analyses the effectiveness of sublingual allergen-specific immunotherapy with sublingual house dust mite and pollen allergens (early and late spring and autumn grass mixture) in patients with seasonal allergi...
Possible Applications of Levocetirizine in the Treatment of Bronchitis and Pneumonia in Children with Atopic Conditions
The article deals with one of the global problems of the world of medicine — allergic diseases. Antihistamines are basic agents in the treatment of allergies of different genesis. One of the representatives of competitiv...
The Mechanism of Activated Nitrogen-Containing Metabolites in the Respiratory Tract: Proinflammatory Effect (Part 3)
The literature review presents current data about modulating action of nitrogen monoxide on the inflammatory response and the apoptotic process depending on its concentration. There is demonstrated a dual action of nitri...