Possible Mechanisms for The Effects of Calcium Deficiency on Male Infertility
Journal Title: International Journal of Fertility & Sterility - Year 2019, Vol 12, Issue 4
Abstract
Calcium (Ca) is a significant element that acts as an intracellular second messenger. It is necessary for many physiological processes in spermatozoa including spermatogenesis, sperm motility, capacitation, acrosome reaction and fertilization. Although influences of Ca deficiency on sperm function and male infertility have been widely studied, mechanisms for these abnormalities are not well considered. Poor sperm motility, impairment of chemotaxis, capacitation, acrosome reaction and steroidogenesis are the major mechanisms by which Ca deficiency induces male infertility. Therefore, an optimal seminal Ca concentration is required to strengthen sperm function and all steps leading to successful fertilization. Furthermore, identification of these mechanisms provides valuable information regarding the mechanisms of Ca deficiency on male reproductive system and the way for developing a better clinical approach. In this review, we aim to discuss the proposed cellular and molecular mechanisms of Ca deficiency on male reproductive system, sperm function and male fertility. Also we will discuss the valuable information currently available for the roles of Ca in male reproduction.
Authors and Affiliations
Asghar Beigi Harchegani, Ali Irandoost, Mahdiyeh Mirnamniha, Hamid Rahmani, Eisa Tahmasbpour, Alireza Shahriary
Keywords
Related Articles
- EP ID EP469158
- DOI 10.22074/ijfs.2019.5420
- Views 256
- Downloads 0
Comparison of Protamine 1 to Protamine 2 mRNA Ratio and YBX2 gene mRNA Content in Testicular Tissue of Fertile and Azoospermic Men
Background Although aberrant protamine (PRM) ratios have been observed in infertile men, the mechanisms that implicit the uncoupling of PRM1 and PRM2 expression remain unclear. To uncover these mechanisms, in this observ...
Male infertility during antihypertensive therapy: are we addressing correctly the problem?
Male fertility significantly decreased in the last 50 years, as showed in several studies reporting a reduction of sperm counts per ml in the seminal fluid. Several “acute” pharmacological treatments, as antibiotics, cou...
Gene Polymorphism of Matrix Metalloproteinase 9 in Asthenozoospermic Male Subjects
Background: Matrix metalloproteinase (MMPs) play important roles in the structural and functional properties of reproductive organs. The aim of this study is to determine the prevalence of C-1562T MMP-9 (rs3918242) gene...
Fertility Preservation in Iranian Cancer Patients: A Continuing Neglect
It is not to be denied that one of the greatest breakthroughs of modern medicine is the day-today improvement in the diagnosis and treatment of cancer. Global statistics show a declining rate of mortality from cancer and...
Expression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy
Background S100P is a member of the S100 family of calcium-binding proteins, and it participates in pathophysiological events, such as tumor growth and invasion. Based on the striking similarities between trophoblast cel...