Potential 5-Fluorouracil Encapsulated mPEG-Chitosan Nanogels for Controlling Drug Release
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2017, Vol 12, Issue 4
Abstract
Aims: The objective of this study was to prepare and characterize poly (ethylene glycol) methyl ether (mPEG)-conjugated chitosan (CS) nanogels, mPEG-CS, at different molar ratios for 5-Fluorouracil (5-FU) delivery (5-FU-loaded mPEG-CS nanogels). Study Design: The chemical cross-linking of those polymers were synthesized by using 4-Nitrophenyl chloroformate as coupling reagent. Place and Duration of Study: Department of Biomaterials & Bioengineering, Institute of Applied Materials Science, Vietnam Academy of Science and Technology, between February and June 2015. Methodology: The chemical structure of mPEG-CS was characterized by Fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1H NMR). Results: The particle sizes of 5-FU-loaded nanogels were nearly spherical in shape with diameter range of 20-50 nm, determined by transmission electron microscopy (TEM). Especially, whereas the encapsulation efficiency and loading capacity of mPEG-CS nanogels were independent of the molar ratio of mPEG, there was one factor that particularly stand out, 5-FU release behavior. Conclusion: These results demonstrated that mPEG-CS nanogels present potential for controlled release of 5-FU working as a delivery system in cancer therapy.
Authors and Affiliations
Dai Hai Nguyen
Keywords
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- EP ID EP311628
- DOI 10.9734/JAMPS/2017/32493
- Views 88
- Downloads 0
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