Potential Advantages of Bone Marrow Sparing IMRT in Cancer Cervix: A Dosimetric Evaluation
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 4
Abstract
ABSTRACT Introduction: Concurrent Chemoradiation (CRT) is the standard of care for locally advanced cervical cancer patients. Addition of chemotherapy to pelvic radiotherapy augments Haematological Toxicity (HT). Whether reducing the radiation dose to Bone Marrow (BM) will diminish HT is yet not clear. Aim: The purpose of the present study was to analyse the feasibility of Bone Marrow Sparing (BMS) in cervical cancer patients using Intensity Modulated Radiotherapy (IMRT). Materials and Methods: Computed Tomography (CT) images of 10 consecutive biopsy-proven invasive cervical cancer patients were used. All patients were treated using Intensity Modulated Radiotherapy (IMRT) without bone marrow sparing (normal-IMRT). BMS-IMRT plans were generated for this study and Dose-Volume Histogram (DVH) parameters were then compared with normal-IMRT plans. Results: The mean values of the Planning Target Volume (PTV) V95 and V97 were lower and were statistically significant (p=0.016 and 0.019 respectively) in BMS-IMRT when compared to normal-IMRT, however, PTV coverage was not compromised in any BMS-IMRT plan. There was no statistically significant difference in the mean values of rectum V30, V40, bowel V35, V40, V45, and femoral head V35. However, the mean values of rectum V50, bladder V40, V45, and V50 were statistically lower in the case of BMS-IMRT. When compared to normal-IMRT the mean values of Pelvic Bone Marrow (PBM) V10, V20, V30, V40 were lower and found to be statistically significant in BMS-IMRT. Conclusion: The BMS-IMRT spares the PBM without compromising the target volume and at the same time spares bladder and rectum more effectively.
Authors and Affiliations
Neha Gupta, Chandra Prakash, Kalpak Chakrabarty, Upendra Giri, Ankita Patel, Sunil Choudhary
Keywords
Related Articles
- EP ID EP553279
- DOI 10.7860/JCDR/2019/39841.12745
- Views 34
- Downloads 0
Role of Multi Detector Computed Tomography (MDCT) in Preoperative Staging of Pancreatic Carcinoma
Introduction: Pancreatic carcinoma is one of the leading causes of cancer related death in advanced countries and has shown rising trends in developing countries like India. Increase in the incidence has been linked to r...
Evaluation of Plaque pH Changes Following Consumption of Health Drinks by Children: A Pilot Study
Introduction: With increased trend among people to choose a healthy diet, there is an increased consumption of health drinks by children. Thus, it is important to know their cariogenicity. Aim: To evaluate the effect of...
Prevention of Severe Tongue Biting in a Mentally Challenged Patient: A Clinical Report
ABSTRACT Orofacial dysfunctions and habits are the main factors which influence the development of malocclusion and perioral disease. In this context, Orthodontics, a field of Dentistry, is closely associated with the d...
Measurement of Menopausal Symptoms using Greene Climacteric Scale in a Tertiary Care Centre in Uttarakhand, India
ABSTRACT Introduction: Menopause represents an important phase in a woman. Increase in life expectancy has resulted in prolongation of this phase. Aim: To identify the age of onset of natural menopause, associated sympto...
Collodion Baby: A Rare Clinical Entity
Letter to Editor