Assessment of Oxidant-Antioxidant Status and Stress Factor in Recurrent Aphthous Stomatitis Patients: Case Control Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 3
Abstract
Introduction: Despite its vast occurrence, the aetiology of Recurrent Aphthous Stomatitis (RAS) still remains unknown and its aetiology is multifactorial. The factors believed to be associated with the aetiology of RAS, may disturb the equilibrium of oxidant-antioxidant status of the organism and may accelerate the formation of free radicals, resulting in Oxidative Stress (OS). Psychological stress is believed to act as a triggering factor or modifying factor for RAS. Aim: To find whether oxidant-antioxidant status and psychosocial stress play a role in the pathogenesis of RAS. Materials and Methods: The study was conducted on 60 subjects over a period of one year (August 2014-August 2015) equally divided into two groups-patients with RAS and healthy controls. Psychosocial stress was analyzed by using Recent Life Changes Questionnaire (RLCQ). Saliva was analyzed to evaluate Superoxide Dismutase (SOD) and Glutathione Peroxidase (GSHPx) activities, Malondialdehyde (MDA) and Uric Acid (UA) levels in both the study and the control groups, using UV spectrophotometry. Results: The mean value of salivary SOD and MDA was increased while the activity of GSHPx and UA decreased in the study group when compared to the controls; the difference being statistically significant (p<0.005). The mean RLCQ stress score was also found to be increased in the RAS group, which showed elevated levels of mental stresses when compared to physical stresses. No significant association was observed between SOD, MDA, GSHPx and UA with high levels of stress score (p>0.05). In the study group, no correlation was observed between the study variables and gender, the number of ulcer episodes in one year, the number of ulcers per episode or the duration of ulcers. Conclusion: This study shows that salivary antioxidant levels show a significant difference in response to OS in RAS patients. An increase in levels of psychosocial stress is seen associated with patients with RAS indicating its ro
Authors and Affiliations
Sherin Ziaudeen, Rathy Ravindran
Keywords
Related Articles
- EP ID EP336733
- DOI 10.7860/JCDR/2017/22894.9348
- Views 102
- Downloads 0
The Effect of Metformin as an Adjunct Therapy in Adolescents with Type 1 Diabetes
Introduction: The strict control of blood glucose levels in adolescents with Type 1 Diabetes Mellitus (T1DM) is accompanied with a considerable long term decrease in microvasular and macrovascular complications. Aim: Thi...
Predictive Regression Equations of Flowmetric and Spirometric Peak Expiratory Flow in Healthy Moroccan Children
Introduction: Peak Expiratory Flow (PEF) has never been characterised among healthy Moroccan school children. Aim: To study the relationship between PEF and anthropometric parameters (sex, age, height and weight) in heal...
Is Obesity a Concern in Breast Cancer?
ABSTRACT Introduction: Breast cancer is one of the commonest cancers in women in India. The risk factors also include modifiable ones such as obesity. Obesity has been shown to increase the risk of developing breast canc...
Accuracy and Precision of Measured Blood Sugar Values by Three Glucometers Compared to the Standard Technique
Introduction: The prevalence of diabetes mellitus has magnified, globally. Being cost effective and user friendly, using the glucometer systems has become more widespread. However, despite their advantages, there are con...
Inhaled Insulin - Current Direction of Insulin Research
Diabetes Mellitus (DM) is a metabolic disorder characterized by relative or absolute deficiency of insulin, resulting in hyperglycemia. Subcutaneous insulin and Oral Hypoglycaemic Agents (OHA) constitute the main treatme...