POTENTIAL ANTIOXIDANT, HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF LEAVES OF HIBISCUS PLATANIFOLIUS LINN
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2011, Vol 3, Issue 3
Abstract
The aim of present study was to investigate antioxidant, hypoglycemic and hypolipidemic effect of leaves of Hibiscus platanifolius Linn on rats and estimation of total phenolic and flavonoids content in ethanolic extract. The study of hypoglycemic activity involves induction of diabetes to rats of all the groups using alloxan (150 mg/kg i.p) followed by subsequent treatment with ethanol and aqueous hot extracts at two different doses each. Glibenclamide (0.5 mg/kg per day for one week) used as a reference standard. Blood glucose, triglycerides, cholesterol, HDL-cholesterol, LDL-cholesterol and total proteins were estimated from the serum by using standard kits. The antioxidant activity was accessed by reducing power and hydrogen peroxide scavenging assay. The total phenolic and flavonoids content was determined by Folin-Ciocalteu and AlCl3 reagent method, respectively. The biochemical parameters were increased in all diabetes rats; there parameters were decreased by the administration of ethanolic and aqueous hot extracts of leaves of Hibiscus platanifolius at dose of 100 mg and 150 mg/kg and are nearly similar to normal levels. Hibiscus platanifolius exhibited its scavenging effect in concentration dependent manner on hydrogen peroxide and property of metal chelating and reducing power. The content of flavonoids was 57 ± 5.4 mg g-1 and that of phenolic was 289.5 ± 5 mg g-1.From this study it has been concluded that the ethanolic and aqueous hot extracts of leaves of Hibiscus platanifolius having good antioxidant, hypoglycemic and hypolipidemic effect.
Authors and Affiliations
D. Saravanan, I. Aparna lakshmi, M. Gobinath, B. Giriesh kumar, S. Priya, E. Syamala, K. Rahamathbee
Keywords
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