Potential antioxidant properties and hepatoprotective effects of Juniperus phoenicea berries against CCl4 induced hepatic damage in rats
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2017, Vol 10, Issue 3
Abstract
Objective: To investigate the antioxidant and hepatoprotective properties of Juniperus phoenicea (J. phoenicea) berries against CCl4-induced oxidative damage in rats. Methods: Hepatotoxicity was induced in albino Wistar rats by single dose of CCl4 dissolved in olive oil (1 mL/kg BW, 1/1 in olive oil, i.p.). Aqueous extract of J. phoenicea berries (AEJP) was administered at the dose of 250 mg/kg/day by gavage for 12 days. Results: Obtained results revealed that administration of CCl4 caused a significant increase in plasma ASAT, ALAT, ALP and LDH activities and total bilirubin concentration, compared to the control group. While, albumin and total protein concentration were significantly lower. Additionally, a significant decrease in the level of hepatic GSH, GPx and GST activities associated with a significant increase of MDA content in CCl4 group than those of the control. However, the treatment of experimental rats with AEJP prevented these alterations and maintained the antioxidant status. The histopathological observations supported the biochemical evidences of hepatoprotection. Conclusions: The results of the present investigation indicate that J. Phoenicea possesses hepatoprotective activity and this effect was may be due to its antioxidant properties.
Authors and Affiliations
Mahfoud Messarah
Keywords
Related Articles
- EP ID EP278503
- DOI 10.1016/j.apjtm.2017.03.005
- Views 76
- Downloads 0
Natural compounds and extracts from Mexican medicinal plants with anti-leishmaniasis activity: An update
Leishmaniasis is considered as an emerging, uncontrolled disease and is endemic in 98 countries. Annually, about 2 million cases of cutaneous and 500000 cases of visceraltype leishmaniasis are recorded and 60000 persons...
Adjuvant activity of Pasteurella multocida A strain, Pasteurella multocida B strain and Salmonella typhimurium bacterial DNA on cellular and humoral immunity responses against Pasteurella multocida specific strain infections in Balb/c mice
Objective: To evaluate the effects of Pasteurella multocida (P. multocida) vaccines on the expression and release of antibodies, interleukin (IL)-6 and IL-12 by serum. Methods: Balb/c mice were immunized with two formali...
Prevalence of hydatidosis in livestocks in Chakwal District of Pakistan
Background: Hydatidosis is a zoonotic parasitic disease and a serious human and animal health problem in many endemic areas of the world. It is caused by the tapeworm parasite of Echinococcus granulosus sensu lato. This...
EPOR mRNA level: A valuable prognostic indicator for patients with ER+ breast cancer
Objective: To explore the expression level and prognostic significance of erythropoietin receptor (EPOR) in patients with breast cancer (BRCA) based on estrogen receptor (ER) status and different molecular subtypes. Meth...
Effect of curcumin on expressions of NF-kBp65, TNF-a and IL-8 in placental tissue of premature birth of infected mice
Objective: To observe the effect of curcumin on expressions of nuclear transcription factor-kappa Bp65 (NF-kBp65), TNF-a and IL-8 in placental tissue of premature birth of infected mice induced by lipopolysaccharide (LPS...