POTENTIAL ANTITUBERCULAR AND SAR STUDY OF SUBSTITUTED [2-(1-BENZOFURAN-2-YL) QUINOLIN-4-YL] METHANOL AND [2-(1-FURAN-2-YL) QUINOLIN-4-YL] METHANOL ANALOGUES
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
ndicating the importance of coupled heterocycles and their important role in the multitude progress of the diseases. In view of this, a series of [2-(1-benzofuran-2-yl) quinolin-4-yl] methanol and [2-(1-furan-2-yl) quinolin-4-yl] methanol (4a-c, 5a-c and 10a-f) were evaluated for their antitubercular activity against H37Rv strain by microplate alamar blue assay (MABA) method. The results revealed that compounds 4a and 5b-c exhibited excellent antitubercular potential at concentration of 1.6 ?g/ml. The compounds 4b-c and 10a-c exhibited good activity at 6.25 ?g/ml and compounds 5a, 10d and 10f showed significant activity at 12.5 ?g/ml when compared with standard drugs pyrazinamide, streptomycin and ciprofloxacin. Furan and benzofuran coupled quinoline moieties are essential for activity as they possess excellent drug like characteristics, suggesting to be potentially best inhibitor of H37Rv strain.
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