Potential Of Soy Protein Isolate As Preventive Agent Of Osteoporosis In Ovariectomized Rats
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2018, Vol 7, Issue 6
Abstract
Objective : The aim of this study was to determine potential soy protein isolate as a preventive agent of osteoporosis on improving bone strength in hipoestrogen condition by comparing the natural product of soy protein isolate with (ethinylestradiol. Material and Method : This study used an experimental method with completely randomized design (CRD). A total of twenty-five 4-month old female Sprague Dawley rats were randomly assigned to five treatment groups (non ovariectomized; ovariectomized (OVX); ovariectomized+ estradiol 10 µg/kg/day (OVX+E2); ovariectomized + soy protein isolate 0.54 g/g/d (OVX+SPI1); ovariectomized+soy protein isolate 2.16 g/g/d (OVX+SPI2)). Rrats were euthanized after 30 days treatment and tibia bones were collected for the assesment of bone Ca and P levels and measure of bone strength using UTM (universal testing machine), and liver were collected to asses MDA levels. Bone strength is obtained by using a UTM tool with the principle of maximum strength in the weight-bearing bone by bone surface area. Result : Soy protein isolate were increased bone calcium and phosphorus levels significantly (P <0.05) compared to all groups treatment.Ovariectomized rats + SPI diet alsoincreased bone strengthsignificantly up to 40.26% compared with the other groups (P<0,05). Ovariectomized rats + estradiol diet had higher level of Ca and P and greater of bone strength levels than in ovariectomized rats group. Dietary soy protein isolate with a 2.16 g/g/d dose were able to reducelevels of MDA (P<0,05). Conclusion : Result of this studys suggest that soy protein isolate diet had potential as preventive agenton bone loss with demonstrated to elevate levels of boneCa and P and improved bone strength significantly. Soy protein isolate also hadpotential as an antioxidant activity by reduced levels of MDA in ovariectomized rats.
Authors and Affiliations
Arria Janovie, Aryani S. Satyaningtijas, Hera Maheswari, Koekoeh Santoso, Nastiti Kusumorini
Keywords
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