PPARs and their role in cancer
Journal Title: OncoReview - Year 2011, Vol 1, Issue 4
Abstract
Peroxisome proliferator activated receptors are members of a very common group of steroid nuclear receptors. The aim of the study was to present actual knowledge regarding the role of PPAR in cancerogenesis. Three types of PPAR are identified: PPARα, PPARβ/δ and PPARγ. They all belong to the superfamily of nuclear receptors and are similar to vitamine D receptor, thyroid hormone receptor and retinoid receptor. In physiological conditions PPAR participates in adipocyte differentiation, lipid storage, regulation of inflamatory reaction as well as in glucose metabolism. Since 1990s the role of PPAR in cancerogenesis has been emphasised. PPARα plays a significant role in cancerogenesis of hepatocellular cancer. Activation of PPARβ/δ is crucial in developing the colorectal cancer in patients with familial adenomatous polyposis. The role of PPARγ in cancerogenesis is more complex. PPARγ can inhibit proliferation of cancer cells and they have some antiangiogenic and proapoptic activity in tumor. So far the clinical use of PPAR ligands as anticancer agents is limited to phase I and II clinical trials, available results of which are unclear.
Authors and Affiliations
Łukasz Głogowski, Anna Żmuda-Siedlarczyk, Andrzej Witkoś, Zofia Rusinowska, Teresa Kokot, Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel
Keywords
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