Pre and Post Renal Transplant Bone Disease: A Prospective Study.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
Introduction:Renal transplants have been performed over 40 years, and there is now long-term data about the bone disease in these patients. Although many aspects of Renal osteodystrophy improve, the bone density and strength may worsen due the adverse effects of immunosuppression. Material & Methods: A total of 45 patients who underwent first renal transplantation at our institute over 2 year period (January 2005 to December 2006) were recruited in the study.All the above patients were followed from 3 months before till 6 months after renal transplantation. All patients were subjected to lumbo sacral dual energy x ray absorptiometry (DEXA SCAN) one month before and 6 months after renal transplantation along with para thyroid hormone assay.Results: In 77 % of patients the cause of end stage renal disease was Chronic glomerulo nephritis and chronic interstitial nephritis constituted 23% . There is a trend towards osteoporosis (25.6%) and osteopenia (25.6%) post renal transplant and normal bone mineral density was found only in 48.8% of patients. Low turnover bone disease was the predominant bone disease in the post renal transplant state.High cumulative steroid dose of more than 4 grams was associated with osteoporosis and osteopenia.Conclusions: Metabolic bone disease is common in pre and post-transplant states.Only 49% had normal bone mineral density by DEXA post-transplant.Remaining 51% had osteopenia or osteoporosis probably due to high doses of gluco corticoid use & persistence of hyper parathyroidism.
Authors and Affiliations
Dr. GondiSiva Rama Krishna, Dr. Degala Vani
Keywords
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- EP ID EP572142
- DOI 10.9790/0853-1804030611.
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