Preclinical evaluation of a novel compound, 4-chlorothiophene for analgesic activity in swiss albino mice
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Background: Pain is one of the most common sensory and emotional experiences which may lead to physiological and psychological stress. Analgesic drugs are commonly used to alleviate pain sensation in several health illnesses. Chronic use of currently available analgesics such as opioids and nonsteroidal antiinflammatory drugs (NSAIDs) may cause several adverse effects in the body.Still there exists a need for search of an ideal analgesic. Aim: To evaluate the analgesic activity of a novel compound, 4-chlorothiophene in Swiss albino mice.Material and methods:The central analgesic activity of 4-chlorothiophene was evaluated by eddy’s hot plate method and early phase of formalin test whereas peripheral activity was evaluated by the late phase of formalin test. Results:40 mg/kg dose of 4-chlorothiophene has shown maximum Pain Inhibition Percentage (PIP) of 35.41% when compared to 128% by morphine in eddy’s hot plate method. Under formalin test, it has shown 19.28% in early phase and 42.55% in late phase compared to 17.72% and 47.37% by aspirin. The results were statistically significant with p<0.05.
Authors and Affiliations
Kummara Muni Kumar, Gondi Surendra kumar
Keywords
Related Articles
- EP ID EP377171
- DOI 10.9790/0853-1707024247.
- Views 44
- Downloads 0
Day Care Laproscopic Cholecystectomy – A Prospective Study
A study was conducted at Rajindra Hospital Patiala in fifty cases undergoing Laparoscopic cholecystectomy from August 2010 to August 2011. The study was conducted on selected patients who fulfilled the pre-set inclusion...
Comparison of The Surface Area Coverage of The Impressions Made of Impression Compound And Alginate: An in Vitro Evaluation.
Introduction: The history of complete denture impression procedures have been influenced largely by the development of impression materials from which new techniques arose. Selection of material is left to the desertion...
To Correlate Clinical Diagnosis with Histopathology and DIF Pattern of Autoimmune Based Vesiculobullous Disorders In A Tertiary Teaching Hospital
Many skin diseases present with blisters but only in some of them blisters occur as the primary event. It is this group of disorders, which is traditionally termed the “vesiculobullous disorders”. Vesicle is a raised les...
A comparative study on Socio-demographic profile of patients Associated with HIV-TB Co-infection registered in ART Centre at central India.
Background:. The worrisome aspect of HIV/AIDS is not limited to the disease itself, but co-infection with Tuberculosis is also one of the challenging problems in developing countries. Materials and Methods: After obtaini...
An In-Vitro Evaluation of Remaining Dentine Thickness through Cbct Using Different Files
Aim: The study was to evaluate the effect of multiple file system (Revo S) versus single file system (one shape) on the dentine thickness in the root canal. Materials and Methods: In this study, 30 freshly extracted huma...