Preclinical evaluation of hepatoprotective activity of Grewia hirsuta extract on ethylene glycol induced liver damage in Wister albino rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 6
Abstract
The extract of Grewia hirsuta were screened for its Hepatoprotective activity in ethylene glycol induced liver damage in Wister albino rats. The extracts at dose of 250, 750 mg/kg were administered orally once daily. The substantially elevated serum enzymatic levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transminase (SGPT), serum alkaline phosphatase (ALP) total bilirubin, SOD and catalase were restored towards normalization significantly by the extracts. Cystone was used as standard reference and exhibited significant Hepatoprotective activity against ethylene glycol induced hepatic damage in rats.
Authors and Affiliations
Shaik Rabbani Basha, Revena Siddapa D, Shaik Jilani, Gowtham Kumar K,Veena V
Keywords
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