PRECLINICAL EVALUTION OF ANTIUROLITHIATIC ACTIVITY OF SWERTIA CHIRATA STEMS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 8
Abstract
The aim of our present study is to evaluate preventive effect of swretia chirata drug in experimentally induced urolithiasis model in rat. Rats were induced to produce renal stone by providing them 0.75% v/v ethylene glycol in drinking water for 28 days. In addition to this methanolic extract of Swertia chirata low dose and high dose i.e. 250 mg/kg and 500 mg/kg were administered along with ethylene glycol for 28 days. After 28 day, the urine, blood and kidney samples were collected from each animal and used for the estimation of various levels of promoters, inhibitors and antioxidant parameters. The ethylene glycol feeding resulted in an increased level of promoters with a decreased level of inhibitors as compare to normal control rats. All these conditions were significantly reversed with treatment of Swertia chirata. Histopathological analysis also reveals deposition of calcium oxalate crystals and disruption of tubular cells and juxtaglomerular cells. That deposition and disruption were also reduced in rats treated with Swertia chirata. These data suggest preventive effect of Swertia chirata against urolithiasis.
Authors and Affiliations
RK Parmar , NR Kachchi , PR Tirgar , TR Desai , PN Bhalodiya
Keywords
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