Preclinical Investigation of Styptic (Anti-hemorrhagic) activity of Siddha Formulation Maampisin Chooranam in wistar rats
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 9
Abstract
Hemorrhages are considered to be one of the potential and leading causes of death throughout the world. Clinical conditions such as menorrhagia, hemorrhoids, stroke are the most common forms of hemorrhages which inclusive of surgical interventions, traumatic injury that has been encountered by the people.Controlling hemorrhage will always remain a top priority in trauma care, and the development of materials to achieve this goal more effectively is of obvious benefit. In Allopathic system of medicine there are only limited drugs that can halt the progression of the hemorrhage. Siddha system of medicine is linked to life style and culture of the people. Siddhars lay great emphasis on strict observance of discipline(daily activities), seasonal discipline, and food regulations. According to Siddhars diseases are not only due to improper and excessive food but also due to the derangement in basic character of human being.Now herbal medicines are regarded as valuables because of its proximity to nature and trend to accept herbal medicines worldwide have been increased. A scientific investigation of medicinal plants not only demonstrates a particular type of activity which has been reported in ancient literature but also time emerges produces some unexpected activity. The main aim of the present investigation is to evaluate the styptic activity (anti hemorrhagic) of Maampisin Chooranam (MC).The results of the study reveals that treatment with MC at the dose of 100 and 200 mg/kg has shown significant decrease in bleedingtime,clotting time, prothrombin time, activated partial thromboplastin time and fibrinogen time in treated rats. From the results it was concluded that the siddha formulation MC has greater potential of preventing hemorrhage and may be used for clinical management of hemorrhage, where in further clinical investigation has been required to justify the present preclinical results.
Authors and Affiliations
A. Dhivyabharathi*1 , S. Brunda2 N. Anbu3 , K. Kanakavalli4
Keywords
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- EP ID EP551677
- DOI 10.22192/ijcrms.2018.04.09.003
- Views 133
- Downloads 0
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