Preclinical studies for a cationic liposome formulation containing Il-2 Intended for the treatment of Human Tumors
Journal Title: Archives of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 2, Issue 1
Abstract
Human cervical cancer tumours expressing the IL-2 receptor (IL-2R) were induced in the peritoneal cavity of nude mice. The tumours were significantly reduced by the i.p. administration of either free IL-2 or liposomes containing this growth factor. No toxicity was observed in the mice even at the highest doses of IL-2 in liposomes. We did not detect any IL-2 in the blood plasma pointing to a strong retention of the liposomes on the cavity. We concluded that this preclinical study for the treatment of tumours expressing IL-2R in the peritoneal cavity is effective and safe. The liposomes were stable and their IL-2 active for up to one year when kept at -14oC in a cryopreservation media approved by the FDA for human use.
Authors and Affiliations
Maria Teresa Corona- Ortega, Arturo Valle- Mendiola, Leonor Aguilar- Santelises, Araceli Garcia del Valle, Rosalva Rangel- Corona, Benny Weiss- Steider
Keywords
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- EP ID EP560293
- DOI 10.29328/journal.apps.1001010
- Views 37
- Downloads 0
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