Application of the Pyphagor’s Theorem for Correction of Ki and Ka constants of enzyme inhibition and activation
Journal Title: Archives of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 2, Issue 1
Abstract
The analysis of dependence of the length projection of Li vectors of biparametrical inhibited and activated (La) enzymatic reactions from the length projection of vectors of monoparametrical inhibited and activated enzymatic reactions on the basic σ0 plane in three-dimensional coordinate system, allows to deduct the quadratic forms of equations for the correction of the constants of inhibition (ki) and activation (Ka) of enzymes. Examples of correction of constants are given.
Authors and Affiliations
VI Krupyanko, PV Krupyanko
A Further Example Showing Efficiency of a Modeling Method Based on the Theory of Dynamic Systems in Pharmacokinetics
Aims: To present a further example showing an efficiency of a modeling method based on the theory of dynamic systems in pharmacokinetics. Study design:The goals of the current study were twofold: to present (1) a furthe...
Application of the Pyphagor’s Theorem for Correction of Ki and Ka constants of enzyme inhibition and activation
The analysis of dependence of the length projection of Li vectors of biparametrical inhibited and activated (La) enzymatic reactions from the length projection of vectors of monoparametrical inhibited and activated enzym...
Some Aspects of medicine distribution in Sudan
The strategy of price liberalisation and privatisation had been implemented in Sudan over the last decade, and has had a positive result on government deficit. The investment law approved recently has good statements and...
Preclinical studies for a cationic liposome formulation containing Il-2 Intended for the treatment of Human Tumors
Human cervical cancer tumours expressing the IL-2 receptor (IL-2R) were induced in the peritoneal cavity of nude mice. The tumours were significantly reduced by the i.p. administration of either free IL-2 or liposomes co...
Diazepam Withdrawal Expression is related to Hippocampal NOS-1 Upregulation
Background: Benzodiazepines are usually prescribed for anxiety and sleep disorders in a long-term fashion that may cause drug dependence. Discontinuation after prolonged administration may lead to withdrawal expression,...