Preclinical studies on comorbidity between depression and psychostimulant addiction.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 6
Abstract
Several clinical data indicate that depression is frequently comorbid with psychostimulant (cocaine, amphetamines) addiction. This short review summarizes preclinical results and observations showing how reward processes are modified in animal models of depression, and which depression-like effects are induced in experimental animals withdrawn from chronic treatment with psychostimulants.
Authors and Affiliations
Małgorzata Filip, Joanna Jastrzębska, Karolina Wydra, Edmund Przegaliński
Immobility stress induces depression-like behavior in the forced swim test in mice: effect of magnesium and imipramine.
Previously, we demonstrated antidepressant-like effect of magnesium (Mg) in the forced swim test (FST). Moreover, the joint administration of Mg and imipramine (IMI) at ineffective doses per se, resulted in a potent redu...
Influence of ABCB1, CYP3A4*18B and CYP3A5*3 polymorphisms on cyclosporine A pharmacokinetics in bone marrow transplant recipients.
The aim of this study was to retrospectively evaluate the effect of polymorphisms in the CYP3A4, CYP3A5 and ABCB1 genes on the dose-adjusted concentration and dose requirement of cyclosporine A(CsA) in Chinese recipients...
Frequency-dependent inhibition of antidromic hippocampal compound action potentials by anti-convulsants.
Using rat hippocampal slices, extracellularly recorded antidromic compound action potentials (cAP) were produced in CA1 pyramidal cell populations by electrical stimulation of the alveus at 0.5 Hz. These responses were a...
Abstracts of the Third Conference on PROGRESS IN EPILEPTIC AND ANTIEPILETIC DRUGS.
Influence of specific endothelin-1 receptor blockers on hemodynamic parameters and antioxidant status of plasma in LPS-induced endotoxemia.
The potent vasoconstrictor endothelin-1 has been implicated in the pathogenesis of plasma oxidative stress seen in sepsis. The selective endothelin receptor blockers BQ123 and BQ788 were used to investigate the importanc...