Preclinical toxicological evaluation of Aloe vera health drinks in wistar rats
Journal Title: International Journal of Research in Pharmaceutical Science and Technology - Year 2018, Vol 1, Issue 1
Abstract
Human consumption of Aloe vera as a beverage has recently increased in popularity. These benefits are controversial with some sources pointing out that the putative effects of aloe are unsupported by clinical studies; it is important that marketed products be tested for toxicities following oral consumption. Hence this study was designed to evaluate the toxicological effect of marketed aloe health drinks. Thirty either sex Wistar rats (200-300gm) were enrolled in this study and are divided into 5 groups. Group I receives Normal saline serves as vehicle control, Group II and III receives Product A- Low dose (0.5 ml twice daily, p.o) and High dose (1.0 ml twice daily, p.o) respectively. Group IV and V receives Product B- Low dose (0.5 ml twice daily, p.o) and High dose (1.0 ml twice daily, p.o) respectively. Weekly body weight and daily feed intake were measured. On 28th day total urine output volume, faecal consistency, Haematological, biochemical, and organ weight were measured to assess the toxicity of aloe health drinks. The result of this study shows that continuous usage of aloe health drinks showed milder weight reduction, significant improvement in erythropoiesis also it increases the WBC count and increases the weight of spleen it may confirm the immune modulatory effect of aloe health drink. At the higher doses, it increased the SGOT, SGPT, serum urea and creatinine it may lead to the hepatotoxicity and nephrotoxicity. In gastrointestinal tract on prolonged uses, it produced few lesions and diarrhoea. It might be concluded that prolonged consumption of unprocessed aloe health drink contains latex, an ingredient which has many health risks associated with it. So it can aggravate health problems.
Authors and Affiliations
P Sudhakar, V Vinoth Prabhu, B Jamuna, R. S Adithya, Lakshmi soman, Anu Joy, R Anand
Keywords
Related Articles
- EP ID EP548806
- DOI 10.33974/ijrpst.v1i1.33
- Views 76
- Downloads 0
Anthelmintic activity of leaves extracts of Olea europaea on Pheretima posthuma
Parasitic roundworms (nematodes) cause substantial morbidity and mortality in livestock animals globally and considerable productivity losses to farmers. The control of these nematodes has relied largely on the use of a...
Development and validation of new analytical method for the simultaneous estimation of amitriptyline and perphenazine in bulk and pharmaceutical dosage form by RP-HPLC
A new, simple, precise, accurate and reproducible RP-HPLC method for simultaneous estimation of Amitriptyline and Perphenazine in bulk and pharmaceutical formulations was developed. Separation of Amitriptyline and Perphe...
Enhancement of dissolution rate of Olmesartan medoxomil using urea as carrier by different solid dispersion techniques
The poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. As per Biopharmaceutical Classification System (BCS), Olmesartan belongs...
Bromelain as an anti-inflammatory and anti-cancer compound
Inflammation is a complicated problem for today’s human beings. Large numbers of people have been diagnosed with arthritis along with inflammation. This is beside the others that suffer inflammation caused by an injury....
Role of cationic lipids for the formulation of lipoplexes
Cationic lipids are widely used for their advantages over viral gene transfer as they are non-immunogenic and their production is easy. The formation of cationic liposomes to lipoplexes with the help of cationic lipids h...