Prediction of Drug Clearance in Children: an Evaluation of the Predictive Performance of Several Models
Journal Title: The AAPS Journal - Year 2014, Vol 16, Issue 6
Abstract
The online version of this article (doi:10.1208/s12248-014-9667-7) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Iftekhar Mahmood, Carl-Michael Staschen, Kosalaram Goteti
Keywords
Related Articles
- EP ID EP681740
- DOI 10.1208/s12248-014-9667-7
- Views 78
- Downloads 0
Targeted lipidomics: Discovery of new fatty acyl amides
The discovery of endogenous fatty acyl amides such asN-arachidonoyl ethanolamide (anandamide),N-oleoyl ethanolamide (OEA), andN-arachidonoyl dopamine (NADA) as important signaling molecules in the central and peripheral...
Glycylsarcosine uptake in rabbit renal brush border membrane vesicles isolated from outer cortex or outer medulla: Evidence for heterogeneous distribution of oligopeptide transporters
Studies were initially performed in rabbit brush border membrane vesicles (BBMV) prepared from whole cortex plus outer medulla. In these studies using combined tissues, two distinct peptide/H+ transport systems were foun...
Pharmacokinetics in mice implanted with xenografted tumors after intravenous administration of tasidotin (ILX651) or its carboxylate metabolite
The pharmacokinetics of tasidotin (ILX651), a depsipeptide currently in phase II for the treatment of advanced solid tumors, and tasidotin-C-carboxylate, the main metabolite, were characterized in male nude mice implante...
The Use of Clinical Utility Assessments in Early Clinical Development
A quickly realizable benefit of model-based drug development is in reducing uncertainty in risk/benefit, comprising individually of safety and effectiveness, two key attributes of a product evaluated for regulatory appro...
A mechanism-Based Approach for Absorption Modeling: The Gastro-Intestinal Transit Time (GITT) Model
The online version of this article (doi:10.1208/s12248-012-9324-y) contains supplementary material, which is available to authorized users.