Prediction of Insensate Peripheral Neuropathy in Diabetics using “Semmes-Weinstein Monofilament” Examination
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2016, Vol 6, Issue 12
Abstract
Background & Objective Diabetic Peripheral neuropathy (DPN) is a debilitating long term complication of Diabetes Mellitus, but has the advantage of being diagnosed early and its course slowed. The Semmes-Weinstein Monofilament examination is appropriate for early diagnosis of neuropathy, as a simple screening instrument generalizable to the clinical setting. The aim of this project is to study the incidence of peripheral neuropathy among diabetics using the 5.07/10 g Monofilament, and determine the most sensitive site on the foot for its use. Methods A random sample of 120 patients were studied. Monofilament was applied to the plantar surface of 4 sites of both feet. Inability to perceive the sensation at any one site before the monofilament bends within a contact time of 2 seconds, was considered abnormal. The data were analyzed using SPSS 17 Statistical Program. Two-sample t-Test was done to study the prevalence. Results and Interpretation Total of 42.5% subjects were recently (less than or equal to one year) diagnosed as cases of diabetes. Out of these subjects, 27% had already some form of neuropathy present in their feet. It was observed that the duration of morbidity significantly affects the setting in of neuropathy among diabetics (p = 0.005), especially patients with diabetes for over 10 years tend to develop neuropathic symptoms over time. The most commonly affected site was found to be the plantar aspect of the great toe of the left foot (83%), in accordance with the gait cycle. Conclusions The management of DPN needs to be individually based on co morbidities and tolerability to medications. Determination of an appropriate site for testing the Monofilament reduces the possibility of false negatives, and makes this bed side tool more suitable for use for determination of neuropathy.
Authors and Affiliations
Archith Boloor, Snigdha Bhatia, Jagadish Rao Padubidri
Keywords
Related Articles
- EP ID EP183041
- DOI -
- Views 136
- Downloads 0
Novel Vesicular Carrier for Enhanced Transdermal Delivery of Tramadol Hydrochloride Transfersomal Gel
The main aim of current probe is to formulate and evaluate transfersomal gel for effective transdermal delivery of Tramadol Hcl. It was investigated by encapsulating the drug in various formulations which composed of var...
The Cerebral Hemodynamic Mechanism of Transient Global Ischemia Using Two-Photon Microscopy
The bilateral common carotid artery occlusion (BCCAO) model simulates the effects produced by the systemic decrease in blood flow, affects the entire brain, and resembles transient global cerebral ischemia in clinical in...
A Study of Intermediate Syndrome in Organo Phosphorus Compound Poisoning in Rural Area
Poisoning with organophosphorus compounds is one of the commonest forms of poisoning in our country. Patients with organophosphorus poisoning present with the symptoms and signs of acetylcholine excess, which is called a...
Ensuring the Survival of Pier Abutment: A Case report
Comprehensive treatment planning is an important aspect before actively undertaking the actual treatment procedures, even in similar looking clinical situations. The biomechanics of most commonly used fixed-fixed bridges...
Bifidobacterium Longum as an Orally Administered Carrier of LL-37 to Treat Bacterial Diarrhea
LL-37 is the only antibacterial peptide of the cathelicidin family found in the human body. It has antimicrobial activity and is able to neutralize endotoxins, with no obvious toxic effects on probiotics. In the present...