Prediction of severity of dengue infection in children based on hepatic involvement
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
The aim of study is to know the severity of dengue illness in children based on range of hepatic involvement and to know relation between liver enzyme derangements and severity of dengue illness which can help in prognostication of the disease. This prospective observational study is conducted from January 2016 to December 2016. During the study period 100 cases of serologically diagnosed dengue fever cases were studied for liver involvement. Among these 100 cases 48 were classical dengue fever (DF) and 52 were severe dengue fever (SDF), 51% of the children were within 5-9 years of age. Deranged total bilirubin, serum albumin, AST, ALT and ALP were present in 23%, 79%, 87%, 73% and 80% of patients respectively. The mean total bilirubin and serum albumin levels were 1.48 mg/dl and 2.9 gm/dl respectively. The mean Aspartate Transaminase (AST), Alanine Transaminase (ALT) and Alkaline Phosphatase (ALP) values were 415.7 U/L, 253U/L and 243.8U/L respectively. AST levels were significantly elevated compared to ALT levels. The degree of liver function derangement is significantly high in SDF group as compared to DF group. Mortality is observed in 3(3%) cases. Elevated AST level can be used as a good positive predictive factor in the prognostication of Severe Dengue Fever.
Authors and Affiliations
Dr. M. A. Rahman, Dr. K. V. Ramana Rao, Dr. V. Sravya
Keywords
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- EP ID EP380749
- DOI 10.9790/0853-1708014449.
- Views 85
- Downloads 0
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