Predictive Role of De Ritis Ratio in Biochemical Recurrence After Radical Prostatectomy
Journal Title: The Medical Bulletin of Haseki - Year 2020, Vol 58, Issue 1
Abstract
Aim: To analyze the role of De Ritis (aspartate aminotransferase/alanine aminotransferase) ratio in predicting biochemical recurrence (BCR) after radical prostatectomy (RP). Methods: We retrospectively evaluated 425 patients with localised prostate cancer who underwent RP from 2009 to 2018. Patients with neo-adjuvant treatment, elevated liver enzymes, postoperative early hormone therapy, incomplete clinicopathological data and a follow-up of less than 6 months were excluded from the study. Demographic, clinical, pathological and follow-up data of the patients were recorded. Patients with and without BCR were compared. Sensitivity and specificity of De Ritis ratio in predicting BCR were calculated. Results: According to the maximum value of the Youden index, optimal threshold of De Ritis ratio for BCR was 1.1. Sensitivity, specificity, positive predictive value and negative predictive value were 69.7%, 61.1%, 37.6% and 85.7%, respectively. Multivariate analysis showed that the De Ritis ratio (HR=1.968, p=0.014) was a significant predictor factor for BCR. BCR-free survival rate was significantly lower in patients with higher De Ritis ratio. Conclusion: Our study suggests that elevated De Ritis ratio and detailed pathological findings could be an independent predictive factor for BCR after RP.
Authors and Affiliations
Kaan Karamık, Yasin Aktaş, Ali Yıldız, İbrahim Erol, Ekrem İslamoğlu, Mutlu Ateş, Taha Ölçücü, Kayhan Yılmaz, Murat Savaş
Keywords
Related Articles
- EP ID EP685261
- DOI 10.4274/haseki.galenos.2019.5592
- Views 137
- Downloads 0
Nasopharyngeal Carriage of Potential Pathogenic Bacteria in Healthy Children Living in İstanbul
Aim: The purpose of this study was to determine the prevalence of nasopharyngeal carriage of potentially pathogenic bacteria (especially Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis) in healthy...
Investigation of APC, MLH1 and MSH2 Mutations in Patients with Hereditary Colorectal Carcinoma: A Single Center Experience
Aim: Colorectal cancer (CRC) is the third most common cancer in the world. About 5-6% of all CRCs have a hereditary inheritance related with germline mutations. Mutation screening is carried out with gene panels for CRCs...
The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development
Aim: Primary dysmenorrhea (PD) is among the most common gynecological diseases in young women presenting to emergency department. It has been shown that cytokines played roles in PD pathogenesis. Interleukin-4 (IL-4), a...
Predictive Role of De Ritis Ratio in Biochemical Recurrence After Radical Prostatectomy
Aim: To analyze the role of De Ritis (aspartate aminotransferase/alanine aminotransferase) ratio in predicting biochemical recurrence (BCR) after radical prostatectomy (RP). Methods: We retrospectively evaluated 425 pat...
What is the Most Frequent Cause of Disability in Childhood? An Overview of Cerebral Palsy Spectrum from the Perspective of Rare Diseases
Aim: Cerebral palsy (CP), with its comprehensive definition, is the most common cause of disability in children under the age of 18 years. In rehabilitation-oriented approach, many diseases with different etiologies that...