Predictive Role of HuR Protein Expression Level in Colonic Tumor
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 8
Abstract
HuR is an mRNA-binding protein. Intracellular localization of HuR is mainly found within nucleus, but it could be translocate between the nucleus and cytoplasm. In the cytoplasm HuR Canincrease half-life of certain mRNA target. Since cytoplasmic localization of HuR is essential for its activity, thus, HuR translocation in malignant cells could have prognostic indication. In the present study we aimed to evaluate the significance importance of HuR in the aggressiveness of colorectal adenocarcinoma. To achieve this goal, we have investigated its expression level in adenocarcinoma sample from Iraqi patients, through linking its expression with tumor histopathological variables (stage, grade, grade, and lymph node involvement), by using Immunohistochemical staining method. Study done on 40 colorectal cancer samples and their respective resection margins. Present study demonstrated that, the positive expression rate of integrin HuR in non-tumor colorectal mucosa was significantly lower than that of the colorectal cancer (CRC) tissue (P<0.005). Moreover, when CRC samples breakdown according to histopathological variables, significant differences in expression level of HuR protein when compared with different tumor stage, grade, and LN involvement depending on mean expression ±SE value (P< 0.05, P< 0.05, and P<0.05 respectively). Our results show that high cytoplasmic HuR expression is associated with a poor histologic differentiation, large tumor size, and poor prognosis in colorectal adenocarcinoma. Keywords: Colon cancer, HuR, prognosis, tumor progression, HuR translocation, IHC, histopathology
Authors and Affiliations
Ibrahim Abdulmajeed Altamemi, Rateb F. Abo Khadher
Keywords
Related Articles
- EP ID EP374338
- DOI -
- Views 69
- Downloads 0
Study of Prevalence of Multi-Drug Resistant Tuberculosis in a Tertiary Care Hospital
Pulmonary tuberculosis with multi-drug resistant Mycobacterium tuberculosis is a major cause of concern in many of the developing countries. The present study was carried out to study the prevalence of multi-drug resista...
Dyslipidemia in Type 2 Diabetes Mellitus Patients of Udaipur Population
Dyslipidemia is one of the major risk factors for cardiovascular disease in Diabetes mellitus type 2. It plays an important role in the pathogenesis and progression of micro and macrovascular complication in patients. Th...
Clinical Profile and Management of Incisional Hernia with Special Reference to Use of Polypropylene Mesh: A Case Series
Incisional hernia represents the defect in the parietal abdominal wall fascia through which intra-abdominal or pre-peritoneal contents can protrude due to architectural deterioration of muscular aponeurosis or they may d...
Community Based, Cross Sectional Study on Sickness Absenteeism among Agriculture Workers in Ramanagara District, Karnataka
Abstract: The loss of work in agriculture related activities plays an important role in the productivity. The research or reports on the absenteeism due to sickness are limited and an effort has been made to find the si...
Bacterial Isolates from Mobile Phones of Health Care Workers in a Tertiary Care Hospital, Hyderabad
Mobilephones of health professionals can harbour various potential pathogens and can become source of infection for the patients, self and for family members. The purpose of the study is to isolate and determine the resi...