Predictive Role of HuR Protein Expression Level in Colonic Tumor
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 8
Abstract
HuR is an mRNA-binding protein. Intracellular localization of HuR is mainly found within nucleus, but it could be translocate between the nucleus and cytoplasm. In the cytoplasm HuR Canincrease half-life of certain mRNA target. Since cytoplasmic localization of HuR is essential for its activity, thus, HuR translocation in malignant cells could have prognostic indication. In the present study we aimed to evaluate the significance importance of HuR in the aggressiveness of colorectal adenocarcinoma. To achieve this goal, we have investigated its expression level in adenocarcinoma sample from Iraqi patients, through linking its expression with tumor histopathological variables (stage, grade, grade, and lymph node involvement), by using Immunohistochemical staining method. Study done on 40 colorectal cancer samples and their respective resection margins. Present study demonstrated that, the positive expression rate of integrin HuR in non-tumor colorectal mucosa was significantly lower than that of the colorectal cancer (CRC) tissue (P<0.005). Moreover, when CRC samples breakdown according to histopathological variables, significant differences in expression level of HuR protein when compared with different tumor stage, grade, and LN involvement depending on mean expression ±SE value (P< 0.05, P< 0.05, and P<0.05 respectively). Our results show that high cytoplasmic HuR expression is associated with a poor histologic differentiation, large tumor size, and poor prognosis in colorectal adenocarcinoma. Keywords: Colon cancer, HuR, prognosis, tumor progression, HuR translocation, IHC, histopathology
Authors and Affiliations
Ibrahim Abdulmajeed Altamemi, Rateb F. Abo Khadher
Keywords
Related Articles
- EP ID EP374338
- DOI -
- Views 45
- Downloads 0
Pattern of pulmonary infection and immunological profile of seropositive HIV with pulmonary tuberculosis patients: A tertiary care hospital based study in Odisha
Abstract: There is a growing concern regarding opportunistic infections associated with seropositive HIV with pulmonary tuberculosis. Hence the present study was carried out with an objective to find out the pattern of p...
Legal Responsibility: Knowledge, Attitude and Perception of Doctors Practising in the District of Bamako (Mali)
Abstract: The purpose of our survey was to study the knowledge, attitude and perception of doctors about legal responsibility. It was a prospective cross-sectional study carried out in the health centre of the 4th Commun...
Reviewing moral distress and its related factors from the perspective of hospitals nurse in Neyshabur City 2013
A moral distress is one of the major ethical issues that effects on the identity and integrity of the nurse as a being committed to ethics. This study aims to explore ethical distress and related factors were analyzed fr...
Evaluation of quality of life in open angle glaucoma patients: A prospective study from a tertiary care centre of Madhya Pradesh
To evaluate the quality of life (QoL) of primary open angle glaucoma patients attending a tertiary eye centre. A total 60 patients were included in this study, which were divided into 3 groups i.e. primary open angle Gla...
Abnormal Cervical Smear in a Tertiary Hospital in Nigeria
Cervical cancer is one of the most common cancers affecting women worldwide, constituting 6% of all female malignancies. It is the most common female genital tract malignancy in Calabar, Nigeria. Although the incidence a...