Predictive Value of Duration and Frequency of Macroscopic Haematuria for Stage, Prognosis and Recurrence in Bladder Cancer Patients
Journal Title: The Bulletin of Urooncology - Year 2021, Vol 20, Issue 1
Abstract
Objective: We aimed to investigate the predictive value of duration and frequency of macroscopic haematuria for the stage, prognosis and recurrence rates in primary bladder cancer. Materials and Methods: We retrospectively reviewed the data of our patients diagnosed with primary bladder cancers during 2000-2014. Patients with history of macroscopic haematuria were included. Their haematuria duration and frequency and stage and grade of bladder cancer, recurrence rates, time until recurrence, time until progression and pre-operative use of anticoagulants were evaluated. Results: A total of 331 patients comprising 276 males (83%) and 55 females (16%) were included in the study. The mean age of the patients was 64.0±11.8 (28-93) years. The average haematuria duration was 18.5±33.5 (0-260) months. There were 173 (52%), 106 (32%) and 52 (15.7%) patients with cancer stages of Ta, T1 and T2, respectively. The average follow-up time was 54.0±41.8 (1-268) months. The frequency of haematuria was significantly higher in patients with muscle-invasive bladder cancers than in those with superficial bladder cancers (p=0.010). Similarly, patients with tumour diameter >3 cm reported significantly higher frequency of haematuria than in those with tumour diameter <3 cm (p=0.045). Five patients exclude from study because they did not attend their follow-up. During follow-up recurrences were seen in 89 (32.3%) out of 326 patients, while 237 (72.7%) patients did have any recurrences. Disease progression was reported in 28 (8.5%) patients. The average time periods until recurrence and progression were 25.8±34.7 months and 27.1±34.9 (1-144) months, respectively. Conclusion: We found a significant difference between the frequency of haematuria in patients with muscle-invasive cancers and those with superficial cancers. Also, we found a negative correlation between smoking and the time until recurrence in patients with macroscopic haematuria. No significant relationships were observed between the duration of haematuria and cancer recurrence rates and prognosis.
Authors and Affiliations
Hüseyin Acinikli, Cumhur Yeşildal, Sinan Levent Kireççi, Göksel Bayar, Ahmet Tevfik Albayrak, Elsad Abdullayev, Abdullah Hızır Yavuzsan
Keywords
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- EP ID EP693533
- DOI 10.4274/uob.galenos.2020.1471
- Views 92
- Downloads 0
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