Efficacy of Chemotherapy Combinations in Metastatic Castration-Resistant Prostate Cancer Patients - Do Homologous Recombination Deficiency Affect the Outcomes?
Journal Title: The Bulletin of Urooncology - Year 2020, Vol 19, Issue 4
Abstract
Homologous recombination (HR) is a major repair mechanism of DNA damage. Platin-based agents are known to be more effective in patients with impaired HR mechanism. Previous studies combined platin compounds with docetaxel, but most of these studies did not perform subgroup analysis for HR-deficient patients. Aggressive variant prostate cancer (AVPC) is considered more susceptible to carboplatin. Furthermore, prostate cancers with a higher rate of small cell or anaplastic carcinoma components are more susceptible to carboplatin plus etoposide. We thought that the effect of cabazitaxel plus carboplatin on the progression-free survival might be related to carboplatin alone. In a study that evaluated the effect of cabazitaxel plus carboplatin, the proportion of AVPC patients was higher in the combination group than in the cabazitaxel group. Additionally, the combination of cabazitaxel and carboplatin led to increased toxicity.
Authors and Affiliations
Emre Yekedüz, Güngör Utkan, Yüksel Ürün
Keywords
Related Articles
- EP ID EP691634
- DOI 10.4274/uob.galenos.2020.1555
- Views 112
- Downloads 0
Management of Patients with Urological Cancers in Turkey during the COVID-19 Pandemic: Recommendations of Uro-oncology Association
Coronavirus disease-19 (COVID-19) has been declared as a pandemic by the World Health Organization. The number of cases has increased over time in correlation with the increasing number of testing worldwide. In order to...
Primary Leiomyosarcoma of the Prostate Invading the Rectum and Bladder
Prostate sarcomas originate from the mesenchymal tissues including smooth muscle, fibromuscular stroma, paraganglia, nerves, and blood vessels. They account for less than 0.1% of all prostate tumors and often present wit...
The Key Steps in Robotic Radical Prostatectomy
No summary
Immunotherapy in Prostate Cancer
In recent years, immunotherapy has become an important treatment alternative in the treatment of many cancers. Research on immunotherapy in prostate cancer has been accelerated by obtaining Food and Drug Administration (...
Predictive Value of Duration and Frequency of Macroscopic Haematuria for Stage, Prognosis and Recurrence in Bladder Cancer Patients
Objective: We aimed to investigate the predictive value of duration and frequency of macroscopic haematuria for the stage, prognosis and recurrence rates in primary bladder cancer. Materials and Methods: We retrospectiv...