Predictive values of serum amyloid-A and CRP for infection in febrile neutropenic cancer patients
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2014, Vol 4, Issue 4
Abstract
Objectives: To evaluate predictive values of serum amyloid A (SAA) and C-reactive protein (CRP) for infection and mortality in patients with febrile neutropenia (FEN). Methods: Daily measurement of serum SAA and CRP levels of patients during antibiotherapy for FEN. Results: Sixty-five FEN episodes of 52 patients were evaluated. Median CRP and SAA levels on 1st day of FEN were 137 mg/L (23-420 mg/L) and 547 mg/L (11-1660 mg/L), respectively. For detection of infection of infection the sensitivity, positive predictive value (PPV), and negative predictive value (NPV) of SAA at a level of >80 mg/L were as 100%, 48% and 100%. Whilethe sensitivity, PPV, and NPV of CRP at a level of >50mg/L were as 86%, 47% and 60%, respectively. Predictive values of initial SAA and CRP levels for infection didn’t differ significantly (CRP: p=0.24, SAA: p=0.39). SAA and CRP levels on the last day of FEN course were significant for infection and mortality (for infection: p=0.003 for CRP and p=0.026 for SAA; for mortality: p<0.001 for CRP and p=0.021 for SAA). Both initial and daily SAA and CRP levels correlated with each other positively and statistically significantly (p<0.001). The area under the curve (AUC) on the receiver operating character (ROC) curve for CRP and SAA were 0.72 (p=0.003, 95% CI: 0.59-0.86) and 0.68 (p=0.19, 95% CI: 0.54-0.82), respectively. Conclusions: Despite low predictive values in decision of initial therapy, these parameters would be helpful in decision of modification and evaluation of response to therapy. J Microbiol Infect Dis 2014; 4(4): 128-135 Key words: Fever, neutropenia, febrile neutropenia, C-reactive protein, serum amyloid A
Authors and Affiliations
Ayşe Batırel, Serap Gencer, Serdar Özer, Taflan Salepci
Keywords
Related Articles
- EP ID EP127035
- DOI 10.5799/ahinjs.02.2014.04.0155
- Views 112
- Downloads 0
Measles Morbidity and Mortality Trend in Nigeria: A 10-Year Hospital-Based Retrospective Study in Lagos State, Nigeria
Objective: This hospital-based retrospective cohort study was undertaken with a view to determine the epidemiological trend of measles in Lagos State, Nigeria Methods: Medical records of clinically diagnosed...
Diagnostic value of Cobas Amplicor MTB and Rotorgene Real Time PCR for tuberculous meningitis: A six-year retrospective study
Objective: Tuberculous meningitis (TBM) is the most severe and lethal form of tuberculosis (TB).Bacteriologic confirmation of TBM is difficult and slow. Therefore, most patients receive antituberculosis treatment based o...
Bipolaris spicifera : Diyabetik ve alkol düşkünü bir hastada iyileşmeyen cilt ülserlerinin nadir nedeni
Burada, koyu renkli, toprak ve bitkilerde hastalık yapan bir mantar olan, diyabetli ve alkol bağımlısı bir hastanın yara kültürlerinden ve eksizyonel biyopsi örneklerinden izole edilen Bipolaris spicifera ’nın etken old...
Burkholderia thailandensis kaynaklı cilt enfeksiyonu: Derleme ile Olgu sunumu
Burkholderia thailandensis genetik olarak Burkholderia pseudomallei’ye yakın, melioidosis etkenidir. Bakteri Güneydoğu Asya’da ve Avustralya’nın kuzey kesimi de dahil olmak üzere tropik bölgelerin ortamlarında yaşar. B....
Prevalence of carbapenem resistant Enterobacteriaceae from a tertiary care hospital in Mumbai, India
Objective: The emergence of Carbapenem Resistant Enterobacteriaceae (CRE) in recent times has become a serious threat to public health due to the high mortality, potential dissemination rates and limited treatment option...