Predictor of Diabetes: Correlation between Leucine Concentration and Insulin Resistance
Journal Title: Pharmacology and Clinical Pharmacy Research - Year 2017, Vol 2, Issue 3
Abstract
Leucine catabolism changes among people with central obesity. This condition can lead to metabolic pathway disorder and increased mTORC-1 activation. Downstream signal of mTORC-1 is p70S6K1, which causes phosphorylation of insulin-1 receptor substrate (IRC-1). This study was performed to evaluate correlation between leucine concentration and insulin resistance (IR). This study was a prospective cross-sectional study, involving two groups; control and obese group. General characteristics and blood sample were taken from each subject. Leucin and Homeostasis Model Assesment (HOMA)-IR, as the marker of insulin resistance, were evaluated. The result indicated a significant positive correlation between leucine concentration and insulin resistance value (R=0.351; P=0.006) in central obese men. The higher leucine concentration, the higher the risk of insulin resistance occurrance. Therefore, leucine can be used as a biomarker for early detection of insulin resistance.
Authors and Affiliations
Chyntia R. Wijaya, Indriyanti R. Sukmana, Jutti Levita
Keywords
Related Articles
- EP ID EP353343
- DOI -
- Views 76
- Downloads 0
Secondary Metabolites and Antioxidant Activity of Methanol Extract of Castanopsis costata Leaves
Castanopsis costata (C.costata) leaves were empirically used by people in North Sumatera, Indonesia, as an antioxidant dietary supplement. However, its pharmacological effect has not been scientifically explored. The pur...
Prediction of Binding Mode of Secondary Metabolites in Apium graveolens to Bcl-2
Developing new cytotoxic agent which has minimal effect against normal cell is required to reduce the side effects obtained from the existing chemotherapy agents. Celery (Apium graveolens) showed several pharmacology act...
Plasma Selenium Level based on Dietary Intake in Geriatric Clinic Population at Dr. Hasan Sadikin General Hospital Bandung
Low plasma selenium level was associated with the increasing risk of death in geriatric patients, particularly those with multiple comorbidities. The sufficient level of selenium intake as an antioxidant is necessary for...
Effectiveness of Erythropoietin in Hypertensive Hemodialysis Patients
Chronic renal failure (CRF) is one the most prevalent health problems among the elderly. On the fifth stage of CRF, the patient becomes eligible to hemodialysis. CRF-induced anemia is commonly treated with Erythropoietin...
Efficacy and Side Effects of Deferasirox and Deferiprone for Thalasemia Major in Children
Thalassemia major (TM) is an inherited disease caused by defective or absent of hemoglobin chain synthesis. Regular chelation therapy is necessary to reduce excess iron in several organs of TM patients. The most commonly...