Predictors of Unfavorable Outcome in Meningitis Patients
Journal Title: Nepal Journal of Neuroscience - Year 2010, Vol 7, Issue 1
Abstract
The main objective is to study the predictors of unfavorable outcome in meningitis patients. This is a prospective analytic study of 100 patients with different types of meningitis admitted in Tribhuvan University teaching hospital (TUTH) during 2005/2006. Patients were followed up at 2 weeks, 6 weeks and 12 weeks. Thirty variables were evaluated at presentation and during hospital stay as predictors of unfavorable outcome. Data analysis was done using SPSS version 11.5. The prognostic rule was derived from significant variables. Among 100 patients (62 males and 38 females), 23 died in Hospital. Univariate analysis yielded 15 variables as significant risk factors for mortality. Among them, according to logistic regression analysis, 12 variables were independent predictors of mortality. Patients with 0 to 3 risk factors had no risk of death. Patients with 4 to 6 risk factors, moderate risk group, had mortality rate of 23.1% and patients with 7 or more risk factors, high risk group, had 100% mortality rate. This prediction tool has 100% sensitivity, 100% specificity , 100% positive predictive value and 100% negative predictive value. Risk stratification of patients with meningitis is possible from simple clinical and laboratory variables on admission.
Authors and Affiliations
Niraj Bam, MD
Keywords
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