Preemptive melatonin versus pregabalin for perioperative anxiety and sedation in patients undergoing cataract surgeries: A double blind, prospective randomized clinical trial
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 9, Issue 2
Abstract
Cataract surgery is a day care surgery, mostly in aged patients and is usually done under topical anaesthesia. Using a premedicant with anxiolytic and sedative properties significantly improves comfort of patient and surgeon. We compared oral melatonin (6mg) and pregabalin (150 mg) on perioperative anxiety and sedation in patients undergoing cataract surgery. In this double blind, randomized clinical trial, 80 patients of 40-80 years, of both sex, ASA Ⅰ and Ⅱ, undergoing cataract surgery underwent simple random sampling to either receive oral melatonin 6mg [group Ⅰ] or oral pregabalin 150mg[group Ⅱ] one hour before the surgery. Anxiety and Sedation were assessed using Visual analogue scale [VAS] and Ramsay sedation score respectively just before administering study drug T1, one hour after administering T2 and immediately after cataract surgery T3. Oral melatonin (6mg) given one hour before cataract surgeries had better effect on the trend of perioperative anxiety than pregabalin. Oral Pregabalin(150mg) had a improved sedation score than melatonin which may not be desirable during the postoperative period in day care surgeries like cataract.
Authors and Affiliations
Shwetha Odeyar S, Shilpa H L, Ramesh Kumar PB
Keywords
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- EP ID EP521017
- DOI 10.26611/1015929
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